GEO DataSets

(Submitter supplied) The effect of a long-term calorie restricted diet was evaluated in hippocampus of male mice The dietary intervention was initiated at 14 months of age and continued until 30 months of age

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

10 Samples

Download data: CEL, CHP

(Submitter supplied) We employed dermal fibroblasts isolated from Fgfr3G374Rneo+ mice, which do not express functional Fgfr3 (Fgfr3KO), from Fgfr3G374Rneo- mice with ligand-independent constitutive activation of Fgfr3 (Fgfr3Act) and from wildtype (WT) mice with normal expression of Fgfr3. Total RNA from these murine dermal fibroblasts (passage 4) were extracted and after quality control, were hybridized to the murine genome U74 gene chip. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

3 Samples

Download data: CEL

(Submitter supplied) The goal of this experiment was to identify genes which are differentially regulated between Leishmania major- infected granuloma macrophages from mice resistant (C57 Bl/6) and susceptible (BALB/c) to experimental leishmaniasis

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

12 Samples

Download data: CEL

(Submitter supplied) Diet-induced obesity is the primary determinant of the current epidemic of diabetes. We have explored the role of genetics in this phenomenon, using C57Bl/6 (B6) and 129S6/SvEvTac (129) mice on a low- or high-fat diet. Microarray analysis indicated significant changes in expression levels between B6 and 129 mice in the chromosomal area of Wnt5a and protein kinase C delta (PKC-delta). Thus, caloric efficiency, i.e., the “thrifty gene,” is a dominant-acting genetic determinant of diet-induced obesity in mice and can be linked to a locus on chromosome 14, including genes linked to adipose development and insulin sensitivity.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

45 Samples

Download data: CEL

(Submitter supplied) We utilized oligonucleotide microarrays to measure cellular mRNA decay rates in mock- or reovirus-infected murine L929 cells to determine if changes in host mRNA expression are a consequence of reovirus-induced alterations in cellular mRNA stability.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

47 Samples

Download data: CEL, CHP

(Submitter supplied) We recently reported isolation of various cancer progenitor cells of transgenic c-Myc and c-Raf mouse lung tumors [Reamon-Buettner SM and Borlak J, 2008]. As lung tumors can arise following dysregulation of signalling pathways normally activated during lung development we were particularly interested in investigating the genetic heterogeneity of these cancer cell lines. By whole genome expression analysis we identified two cell lines (A2C12, cRAF_cMYC) to be very different from the remaining tumor cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

24 Samples

Download data: CEL, CHP

(Submitter supplied) Multiple endocrine neoplasia type1 (MEN1), an inherited autosomal dominant syndrome characterized by the development of endocrine tumors including NETs, results from mutation in the MEN1 gene that encodes the protein menin. In mouse models, heterozygous loss of Men1 leads to multiple endocrine tumors with loss of heterozygocity at the Men1 locus. Men1 interacts with several partners to regulate cellular processes and gene expression through regulating histone modification. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

4 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL82 GPL83 GPL81

30 Samples

Download data: CEL

(Submitter supplied) The synthesis of fatty acids and cholesterol is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2. Their function in liver has been characterized in transgenic mice that overexpress each SREBP isoform and in mice that lack all three nuclear SREBPs because of gene knockout of SREBP cleavage-activating protein (SCAP) required for nuclear localization of SREBPs. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

10 Samples

Download data: CEL

(Submitter supplied) We show that macrophages are recruited to ductal hyperplasias that have a high tumor-forming potential where they are differentiated and polarized toward a tumor-promoting phenotype. These studies suggest that therapeutic targeting of tumor-promoting macrophages may not only be an effective strategy to block tumor progression and metastasis, but may also have critical implications for breast cancer prevention. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

11 Samples

Download data: CEL

(Submitter supplied) To gain insights into the genes whose expression levels are altered during stromal cell differentiation (decidualization), gene microarray profiling was performed following the experimentally induced decidualization protocol.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

2 Samples

Download data: CEL, CHP

(Submitter supplied) Pericytes confer vascular stability in the retina, and the loss of pericytes can cause the blood-retina barrier breakdown seen in diabetic retinopathy. To identify endothelial-specific genes expressed in pericyte-deprived retinal vessels, we purified genetically labeled endothelial cells from Tie2-GFP transgenic mice treated with neutralizing antibody against PDGFRb (APB5) and performed gene expression profiling using DNA microarray. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL82 GPL83 GPL81

9 Samples

Download data: CEL

(Submitter supplied) Solar UV represents a ubiquitous environmental physical insult. Thus, to maintain its integrity as an effective barrier, skin must be unusually resistant to cell death. However, UV overexposure causes sunburn1,2 (necrosis and inflammation) and cells that survive harbour damaged DNA, which if not repaired or removed by apoptosis can lead to skin cancer development3-10. CD1d, a transmembrane protein identified in glycolipid antigen presentation11,12 to invariant natural killer T (NKT) cells13,14 is expressed by epithelial cells of most tissues including skin15-17, and shares close homology between humans and mice12. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

9 Samples

Download data

(Submitter supplied) The aim of this study was to better understand the Bid-regulated events during hepatic carcinogenesis. The information from this set of data indicates that wild type and bid-deficient livers express different sets of genes after diethylnitrosamine (DEN) treatment.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

30 Samples

Download data: CEL, CHP

(Submitter supplied) To investigate the role of NKX3.1 in prostate differentiation, we employed transcriptome analysis of mouse seminal vesicle (from 15-month-old Nkx3.1+/+ mice); mouse prostate (from 4-month-old Nkx3.1+/+ and Nkx3.1-/- mice); human prostate cells (RWPE1 cells engineered with empty vector (altered pTRIPZ), NKX3.1 wild type over-expression, and NKX3.1 (T164A) mutant over-expression); and tissue recombinants (generated from combining engineered mouse epithelial cells (seminal vesicle epithelial cells or prostate epithelial cells from 2-month-old mice) and rat UGS mesenchymal cells). more...

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL11154 GPL81 GPL13112

52 Samples

Download data: CEL

(Submitter supplied) Analysis of transcriptome of seminal vesicle from 15-month-old Nkx3.1+/+ mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

4 Samples

Download data: CEL

(Submitter supplied) The purpose of this experiment was to generate a baseline microarray data set in order to investigate natural changes in gene expression profiles from mid pregnancy throuh mid lactation in the murine mammary gland. Four animals per time point were sacrificed, mammary tissue was collected less the lymph node, and data were gathered using MicroArray Suite v.5.0. The resulting data were used to evaluate the differences in gene expression among the timepoints investigated across secretory activation with emphasis on lipid production and secretion. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

20 Samples

Download data: CEL

(Submitter supplied) To study a complex network of gene expression changes underlying c-Myc-triggered carcinogenesis in lung we performed oligonucleotide array analysis of solid lung adenocarcinomas which developed in transgenic mice due to constitutive expression of c- Myc in alveolar type II epithelial cells and compared them with the non-transgenic lung as a control. The microarray analysis yielded 162 up regulated and 301 down regulated genes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

14 Samples

Download data: CEL, CHP

(Submitter supplied) T cell receptor(TCR) engagement in the absence of costimulation leads to a state of T cell tolerance known as anergy. Anergy induction requires new protein synthesis since it is inhibited by cycloheximide. In this experiment, we tried to figure out kinetic properties of the gene expression in anergy induction phase and the subsequent anergy maintenance phase.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL83 GPL82 GPL81

15 Samples

Download data: CEL

(Submitter supplied) Differentiation of naive CD8 T cells into cytotoxic effector cells requires three distinct signals- antigen (signal 1), costimulation -B7-1 (signal 2) and cytokine, either interleukin-12, interferon-a/b, or IL-21 (signal 3). Interaction of naive CD8 T cells with antigen and B7-1 programs cell division and proliferation whereas the presence of cytokines- IL-12, IFNa/b or IL-21 promote survival, differentiation and memory establishment. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

5 Samples

Download data: CEL, CHP