GEO DataSets

(Submitter supplied) Organ transplant recipients (OTRs) on Cyclosporine A (CSA) are prone to catastrophic cutaneous squamous cell carcinoma (SCC). Allograft-sparing, cancer-targeting systemic treatments are unavailable. We have shown increased risk for catastrophic SCC in OTRs via CSA-mediated induction of Interleukin-22 (IL-22). Herein, we found CSA drives SCC proliferation and tumor growth through IL-22 and JAK/STAT pathway induction. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

23 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL570 GPL8300

84 Samples

Download data

(Submitter supplied) Glucocorticoid (GC)- sensitive cells are killed by receptor (GR)-filling concentrations of GC for a sufficient time. We used 3 closely related clones (2 sensitive, 1 resistant) from the CEM line of ALL cells to test the hypothesis that over time, a distinct set of regulated genes would be found in sensitive clones, with cross-talk to other significant pathways

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

72 Samples

Download data

(Submitter supplied) Adenocarcinomas of the prostate arise as multifocal heterogeneous lesions as the likely result of genetic and epigenetic alterations and deranged cell-cell communication. Notch signaling is an important form of intercellular communication with a role in growth/differentiation control and tumorigenesis. Contrasting reports exist in the literature on the role of this pathway in prostate cancer (PCa) development. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

8 Samples

Download data: CEL

(Submitter supplied) Vitiligo Blood Transcriptomics Provides New Insights into Disease Mechanisms and Identifies Potential Novel Therapeutic Targets Abstract Background: Significant gaps remain regarding the pathomechanisms underlying the autoimmune response in vitiligo (VL), where the loss of self-tolerance leads to the targeted killing of melanocytes. Specifically, there is incomplete information regarding alterations in the systemic environment that are relevant to the disease state. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

14 Samples

Download data: CEL

(Submitter supplied) 126 infant leukemia cases registered to NCI-sponsored Infant Oncology Group/Children's Oncology Group treatment trials were studied using oligonucleotide microarrays containing 12,625 probe sets (Affymetrix U95Av2 platform)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

125 Samples

Download data: CEL, RPT, TXT

(Submitter supplied) Affymetrix HG_U95Av2 oligonucleotide microarrays were used to perform gene expression profiling of 254 cases of pediatric ALL in order to determine genes predictive of outcome that may be useful in refining risk classification.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

254 Samples

Download data: CEL, RPT, TXT

(Submitter supplied) We have generated a molecular taxonomy of lung carcinoma, the leading cause of cancer death in the United States and worldwide. Using oligonucleotide microarrays, we analyzed mRNA expression levels corresponding to 12,600 transcript sequences in 186 lung tumor samples, including 139 adenocarcinomas resected from the lung. Hierarchical and probabilistic clustering of expression data defined distinct subclasses of lung adenocarcinoma. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

254 Samples

Download data: CEL, RPT, TXT

(Submitter supplied) Prostate tumors are complex entities composed of malignant cells mixed and interacting with nonmalignant cells. However, molecular analyses by standard gene expression profiling are limited because spatial information and nontumor cell types are lost in sample preparation. We scored 88 prostate specimens for relative content of tumor, benign hyperplastic epithelium, stroma, and dilated cystic glands. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

88 Samples

Download data: CEL

(Submitter supplied) Microarray analysis was used to determine the expression of 12,000 genes in a set of 50 gliomas, 28 glioblastomas and 22 anaplastic oligodendrogliomas. Supervised learning approaches were used to build a two-class prediction model based on a subset of 14 glioblastomas and 7 anaplastic oligodendrogliomas with classic histology. A 20-feature k-nearest neighbor model correctly classified 18 of the 21 classic cases in leave-one-out cross-validation when compared with pathological diagnoses. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

50 Samples

Download data: CEL

(Submitter supplied) Neuroblastoma (NB) tumours have the highest incidence of spontaneous remission, especially among the stage 4s NB subgroup affecting infants. Clinical distinction of stage 4s from lethal stage 4 can be difficult, but critical for therapeutic decisions. The aim of this study was to investigate differential gene expression amongst infant disseminated NB subgroups. Thirty-five NB tumours from patients diagnosed at < 18 months (25 stage 4 and 10 stage 4s), were evaluated gene expression analyses. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

27 Samples

Download data: CEL

(Submitter supplied) Neuroblastic tumours (NBTs) represent a heterogeneous spectrum of neoplastic diseases associated with multiple genetic alterations. Structural and numerical chromosomal changes are frequent and are predictive parameters of NBTs outcome. We performed a comparative analysis of the biological entities constituted by NBTs with different ploidy status. Gene expression profiling of 49 diagnostic primary near-triploid (n= 22) and near-diploid/tetraploid (n=27) NBTs performed using Affymetrix U95Av2 arrays, revealed distinct expression profiles associated with each NBT subgroup. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

49 Samples

Download data: CEL

(Submitter supplied) Prostate tumors are among the most heterogeneous of cancers, both histologically and clinically. Microarray expression analysis was used to determine whether global biological differences underlie common pathological features of prostate cancer and to identify genes that might anticipate the clinical behavior of this disease. While no expression correlates of age, serum prostate specific antigen (PSA), and measures of local invasion were found, a set of genes was identified that strongly correlated with the state of tumor differentiation as measured by Gleason score. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

102 Samples

Download data: CEL, TXT

(Submitter supplied) The incidence of prostate cancer is frequent, occurring in almost one-third of men older than 45 years. Only a fraction of the cases reach the stages displaying clinical significance. Despite the advances in our understanding of prostate carcinogenesis and disease progression, our knowledge of this disease is still fragmented. Identification of the genes and patterns of gene expression will provide a more cohesive picture of prostate cancer biology. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

4 related Platforms

444 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) To identify the specific genes for intestinal-type and diffuse-type gastric cancers.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

30 Samples

Download data: CEL, CHP

(Submitter supplied) Epidermis, a continuously self-renewing and differentiating organ, produces a protective stratum corneum that shields us from external chemical, physical and microbial threats. Epidermal differentiation is a multi-step process regulated by influences, some unknown, others insufficiently explored. Detachment of keratinocytes from the basement membrane is one such pro-differentiation stimulus. Here, we define the transcriptional changes during differentiation, especially those caused by detachment from the substratum. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

2 Samples

Download data: CEL

(Submitter supplied) FCHL is a common, complex genetic lipid disorder with a largely unknown aetiology. Altered adipose tissue metabolism has been implicated as contributing to FCHL. We used microarrays to investigate the mRNA profiles of FCHL patients with CHD and non-FCHL patients with CHD in comparison with non-FCHL, non-CHD patients to define a core set of genes that were differentially expressed in FCHL and to provide a reasonable launch-pad for examining the direct contribution of one of this gene set to the development of adipose tissue.

Organism:

Homo sapiens

Type:

Expression profiling by array

6 related Platforms

120 Samples

Download data: CEL

(Submitter supplied) Inherited genetic variants of insulin receptor induced cellular signaling have long been suspected to contribute to the development of type-2- diabetes mellitus. In this report we discuss a heterozygous mutation in the first coding exon of the proto-oncogene Ha-Ras (Ha-RasA11P) that we have identified in a patient with familial premature aging syndrome. The patient has atopic sklerodermic skin alterations, insulin resistance as well as disturbances in lipid metabolism. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

9 Samples

Download data: CEL

(Submitter supplied) Lipodystrophies resemble syndromes of disturbed adipocyte biology or development and severe congenital forms (CGL) lack adipose tissue. The ubiquitous immediate-early gene c-fos is one essential transcription factor to initiate adipocyte differentiation. In a CGL patient we identified a single homozygous point mutation in the promoter of c-fos gene. The mutation facilitates the formation of a novel specific protein/ DNA complex and ubiquitously reduces basal and inducible c-fos transcription activity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

10 Samples

Download data: CEL

(Submitter supplied) Waldenströms macroglobulinemia (WM) is a rare lymphoproliferative disorder with apparent morphologic and immunophenotypic heterogeneity and its origins are still poorly understood. In this study, using Gene-Expression Profiling (GEP), we compared the global mRNA expression patterns of CD19+ WM B cells (WM-BC) and CD138+ WM plasma cells (WM-PC) with those of normal CD19+ peripheral blood B cells (PB-BC), tonsil-BC (T-BC), CD138+ T-PC and bone marrow PC (N-PC). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL570 GPL8300

102 Samples

Download data: CEL, TXT