GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL82 GPL83 GPL81

30 Samples

Download data: CEL

(Submitter supplied) The synthesis of fatty acids and cholesterol is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2. Their function in liver has been characterized in transgenic mice that overexpress each SREBP isoform and in mice that lack all three nuclear SREBPs because of gene knockout of SREBP cleavage-activating protein (SCAP) required for nuclear localization of SREBPs. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL83

10 Samples

Download data: CEL

(Submitter supplied) Pericytes confer vascular stability in the retina, and the loss of pericytes can cause the blood-retina barrier breakdown seen in diabetic retinopathy. To identify endothelial-specific genes expressed in pericyte-deprived retinal vessels, we purified genetically labeled endothelial cells from Tie2-GFP transgenic mice treated with neutralizing antibody against PDGFRb (APB5) and performed gene expression profiling using DNA microarray. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL81 GPL82 GPL83

9 Samples

Download data: CEL

(Submitter supplied) T cell receptor(TCR) engagement in the absence of costimulation leads to a state of T cell tolerance known as anergy. Anergy induction requires new protein synthesis since it is inhibited by cycloheximide. In this experiment, we tried to figure out kinetic properties of the gene expression in anergy induction phase and the subsequent anergy maintenance phase.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL81 GPL82 GPL83

15 Samples

Download data: CEL

(Submitter supplied) During embryogenesis, nociceptive sensory neurons of the dorsal root ganglia depend intimately on Nerve Growth Factor (NGF) for neuronal survival, maturation and target innervation. NGF is a secreted molecular signal synthesized by neuronal target tissues. In developing nociceptors, NGF engages the receptor tyrosine kinase TrkA to activate a gene transcriptional program involving the regulation of hundreds of transcripts. more...

Organism:

Mus musculus

Type:

Expression profiling by array

4 related Platforms

16 Samples

Download data: CEL, CHP

(Submitter supplied) We previously isolated a subclone, MIN6 clone 4, from the parental MIN6 cells, that shows well-regulated insulin secretion in response to glucose, glybenclamide, and KCl, even after prolonged culture. To investigate the molecular mechanisms responsible for preserving GSIS in this subclone, we compared four groups of MIN6 cells: Pr-LP (parental MIN6, low passage number), Pr-HP (parental MIN6, high passage number), C4-LP (MIN6 clone 4, low passage number), and C4-HP (MIN6 clone 4, high passage number). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL81 GPL83 GPL82

12 Samples

Download data: CEL

(Submitter supplied) Deregulated retinal angiogenesis directly cause vision loss in many ocular diseases, such as diabetic retinopathy and retinopathy of prematurity. To identify endothelial-specific genes expressed in angiogenic retinal vessels, we purified genetically labeled endothelial cells from Tie2-GFP transgenic mice and performed gene expression profiling using DNA microarray. To find out genes associated with angiogenesis, comparisons of microarray data were carried out between GFP-negative non-endothelial retinal cells and GFP-positive retinal endothelial cells in angiogenic P8 retina.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4461 GDS4462 GDS4463

Platforms:

GPL83 GPL82 GPL81

18 Samples

Download data: CEL

Analysis of FACS-sorted, GFP-positive endothelial cells from retinas of postnatal day 8 (P8) homozygous Tie2-GFP transgenics. Deregulated retinal angiogenesis causes vision loss in many ocular diseases. Results provide insight into the molecular mechanisms underlying intraretinal angiogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell type sets

Platform:

GPL83

Series:

GSE27238

6 Samples

Download data: CEL

(Submitter supplied) GeneChip-based screen for genes induced in the initial phase of neural differentiation from ES cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL83 GPL81 GPL82

30 Samples

Download data: CEL, CHP

(Submitter supplied) A mouse AGM-derived cell line, AGM-s3, was shown to support the development of hematopoietic stem cells. To elucidate the molecular mechanisms regulating early hematopoiesis, we obtained subclones from AGM-s3, some of which were hematopoiesis supportive (s3-A9) and others which were non-supportive (s3-A7), and we analyzed the gene expression profiles by gene chip analysis. Keywords: cell type comparison

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL82 GPL83 GPL81

9 Samples

Download data: CEL, CHP

(Submitter supplied) Epidemiological studies have shown that a full-term pregnancy at early age can decrease the breast cancer risk up to one-half. Pregnancy has been shown to prevent carcinogen-induced mammary tumors in rodents as well. The protective effect of pregnancy can be mimicked by administration of estrogen and progesterone to nulliparous rodents in amounts that are similar to those during pregnancy and alters responsiveness of p53 to DNA damage. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL81 GPL82 GPL83

60 Samples

Download data

(Submitter supplied) Oncogenic tyrosine kinases, such as BCR-ABL, TEL-ABL, TEL-PDGF-beta-R and FLT3-ITD, play a major role in the development of hematopoietic malignancy. They activate many of the same signal transduction pathways. To identify the critical target genes required for transformation in hematopoietic cells, we used a comparative gene expression strategy in which selective small molecules were applied to 32Dcl3 cells that had been transformed to factor-independent growth by these respective oncogenic alleles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL83 GPL82 GPL81

66 Samples

Download data: CEL

(Submitter supplied) STAT5A and STAT5B proteins belong to the family of signal transducers and activators of transcription. They are encoded by 2 separate genes with 91% identity in their amino acid sequences. Despite their high degree of conservation, STAT5A and STAT5B exert non-redundant functions, resulting at least in part from differences in target gene activation. To better characterize the differential contribution of STAT5A and STAT5B in gene regulation, we performed single or double knock-down of STAT5A and STAT5B using small interfering RNA. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3349 GDS3350 GDS3351

Platforms:

GPL82 GPL83 GPL81

15 Samples

Download data: CEL, CHP

Analysis of STAT5A and STAT5B depleted pro-B Ba/F3-beta cells stimulated with IL-3 for 0.5 or 2 hours. STAT5A and STAT5B are members of the family of signal transducers and activators of transcription. Results identify IL-3 inducible STAT5 target genes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 protocol, 3 time sets

Platform:

GPL83

Series:

GSE10389

5 Samples

Download data: CEL, CHP

(Submitter supplied) Analysis of gene expression before (P14), during (P28), and after (P60) the critical period for ocular dominance plasticity. Keywords: time course

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3375 GDS3376 GDS3382

Platforms:

GPL83 GPL82 GPL81

30 Samples

Download data: CEL, CHP

Analysis of visual cortices before the critical period for ocular dominance plasticity opens [postnatal day 14 (P14)], at the peak sensitivity of the critical period (P28), and after the critical period (P60). Results provide insight into the molecular mechanisms associated with the critical period.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL83

Series:

GSE11764

10 Samples

Download data: CEL, CHP

(Submitter supplied) To investigate the importance of STAT3 in the establishment of ES cells we have in a first step derived stable pluripotent embryonic stem cells from transgenic FVB mice expressing a conditional tamoxifen dependent STAT3-MER fusion protein. In a second step, STAT3-MER overexpressing cells were used to identify STAT3 pathway-related genes by expression profiling in order to identify new key-players involved in maintenance of pluripotency in ES cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3444 GDS3445 GDS3446

Platforms:

GPL82 GPL81 GPL83

18 Samples

Download data: CEL, CHP

Analysis of cultured embryonic stem (ES) cells overexpressing the transcription factor STAT3. STAT3 is a downstream target of the LIF signaling cascade. LIF activation maintains ES cells in a pluripotent state. Results provide insight into the role of STAT3 in maintenance of ES cell pluripotency.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL83

Series:

GSE11398

6 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

5 related Platforms

10 Samples

Download data: CEL, CHP

(Submitter supplied) Comparison of gene expression levels between matUPD12 and patUPD12 15.5 dpc whole embryo or placenta samples (maternal versus paternal uniparental disomy of Chr 12). Identification of highly differentially expressed transcripts. Keywords: genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

4 related Platforms

8 Samples

Download data: CEL, CHP