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Items: 1 to 20 of 98

1.

Human umbilical vein endothelial cells: Control vs. Uninfected Groups

(Submitter supplied) Experiments compared uninfected ECV304 cells with ECV304 cells infected with HSV-2, and both were tested for differential genes by microarray with the goal of determining the effect of HSV-2 on gene expression in ECV304 cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
2 Samples
Download data: TXT
Series
Accession:
GSE206320
ID:
200206320
2.

Asparagine availability governs metastasis in a model of breast cancer

(Submitter supplied) Single - cell profiling of patient tumours and of mouse models is revealing that many cancers are constituted of communities of genetically and phenotypically distinct clonal lineages 1 - 12. A functional model of breast cancer heterogeneity revealed that clonal sub - populations proficient at generating circulating tumour cells were not equally capable of forming metastases at secondary sites 13. A combination of differential expression and focused in vitro and in vivo RNAi screens revealed candidate drivers of metastasis discriminating these clones, which were then evaluated in gene expression datasets from breast cancer patients. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL5325 GPL1390 GPL887
6 Samples
Download data
Series
Accession:
GSE107109
ID:
200107109
3.

Genome expression profiling identifies host-directed antimicrobial drugs against respiratory infection by nontypable Haemophilus influenzae

(Submitter supplied) Objectives: Therapies being safe, effective and not vulnerable to develop resistance are highly desirable to counteract bacterial infections. Host-directed therapeutics is an alternative to conventional antibiotics based on perturbing host pathways subverted by pathogens during their life cycle by the use of host-directed drugs to counteract microbial infections. This study sought to identify cellular genes and pathways differentially expressed during airways epithelial infection by nontypable Haemophilus influenzae (NTHi). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
8 Samples
Download data: GPR
Series
Accession:
GSE69134
ID:
200069134
4.

Neuroblastoma: MYCN normal vs. MYCN amplified

(Submitter supplied) To evaluate the expression of genes associated with MYCN in NB, 10 tumors with MYCN amplification and 10 with normal MYCN copy number were subjected to oligonucleotide microarray using Agilent oligo microarray chips.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
20 Samples
Download data: TXT
Series
Accession:
GSE53371
ID:
200053371
5.

Adrenocortical Carcinoma Gene Expression Profiling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL887 GPL570
63 Samples
Download data: CEL, TXT
Series
Accession:
GSE19776
ID:
200019776
6.

Adrenocortical Carcinoma Gene Expression Profiling [Agilent]

(Submitter supplied) Adrenocortical carcinoma (ACC) is an aggressive endocrine tumor with a poor 5 year survival rate of 10-20%. We used expression profiling to assess the transcriptional changes associated with ACC as compared to normal adrenal glands with the goal of identifying new targets for treatment. Fourteen ACC tumors were profiled on both Affymetrix U133 Plus 2 or Agilent 22K Human Genome arrays; an additional six tumors were profiled on one or the other array. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
15 Samples
Download data: TXT
Series
Accession:
GSE19775
ID:
200019775
7.

Micro-scale genomic copy number aberrations as another means of mutagenesis in breast cancer

(Submitter supplied) Introduction: In breast cancers, the basal-like subtype has high levels of genomic instability relative to other breast cancer subtypes with many basal-like-specific regions of aberration. There is evidence that this genomic instability extends to smaller scale genomic aberrations as well, as shown by a previously described micro-event in the PTEN gene in the Basal-like SUM149 breast cancer cell line. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array; Genome variation profiling by genome tiling array
8 related Platforms
192 Samples
Download data
Series
Accession:
GSE36889
ID:
200036889
8.

Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals and AT patients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL7260 GPL887 GPL7264
88 Samples
Download data: TXT
Series
Accession:
GSE45850
ID:
200045850
9.

Gene expressioin signatures at basal level in human lymphoblastoid cell lines with different ataxia telangiectasia-mutated (ATM) genotypes

(Submitter supplied) Transcriptional profiling of human lymphoblastoid cell lines with different ATM genotypes at basal level was compared to extract gene expression signatures that can identify ataxia telangiectasia (AT) carries from non AT carries and AT patients.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
24 Samples
Download data: TXT
Series
Accession:
GSE45848
ID:
200045848
10.

Vimentin DNA Methylation Predicts Survival in Breast Cancer

(Submitter supplied) Purpose:The Vimentin gene plays a pivotal role in epithelial-to-mesenchymal transition (EMT) and is known to be over-expressed in the prognostically poor basal-like breast cancer subtype. Recent studies have reported Vimentin DNA methylation in association with poor clinical outcomes in other solid tumors, but not in breast cancer. We therefore quantified Vimentin DNA methylation in breast tumors and matched normal pairs in association with gene expression and survival in a cohort of 83 breast cancer patients. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL5325 GPL1390 GPL887
83 Samples
Download data
Series
Accession:
GSE35629
ID:
200035629
11.

MicroRNA-30c inhibits Human Breast Tumor Chemotherapy Resistance by regulating TWF1 and IL-11: Patient DataSet

(Submitter supplied) Chemotherapy resistance frequently drives tumor progression. However, the underlying molecular mechanisms are poorly characterized. Epithelial-to-mesenchymal transition (EMT) has been shown to correlate with therapy resistance, but the functional link and signaling pathways remain to be elucidated. We report here that miR-30c, a human breast tumor prognostic marker, plays a pivotal role in chemo-resistance by a direct targeting of the actin-transporter TWF1, which promotes EMT. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
6 related Platforms
60 Samples
Download data
Series
Accession:
GSE22049
ID:
200022049
12.

Major functional transcriptome of an inferred center regulator of an ER(-) breast cancer model system

(Submitter supplied) We aimed to find clinically relevant gene activities ruled by the signal transducer and activator of transcription 3 (STAT3) proteins in an ER(-) breast cancer population via network approach. STAT3 is negatively associated with both lymph nodal category and stage. MYC is a component of STAT3 network. MYC and STAT3 may co-regulate gene expressions for Warburg effect, stem cell like phenotype, cell proliferation and angiogenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
102 Samples
Download data: TXT
Series
Accession:
GSE32641
ID:
200032641
13.

NS1 protein of influenza A virus and interferon

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL4133 GPL887
40 Samples
Download data: TXT
Series
Accession:
GSE39202
ID:
200039202
14.

The NS1 protein of influenza A virus suppresses interferon-regulated activation of antigen-presentation and immune-proteasome pathways

(Submitter supplied) The NS1 protein of influenza virus counters host antiviral defences primarily by antagonizing the type I interferon (IFN) response. Both the N-terminal dsRNA-binding domain and the C-terminal effector domain are required for optimal suppression of host responses during infection. To better understand the regulatory role of the NS1 effector domain, we used an NS1-truncated mutant virus derived from human H1N1 influenza isolate A/Texas/36/91 (Tx/91) and assessed global transcriptional profiles from two independent human lung cell-culture models.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL887 GPL4133
32 Samples
Download data: TXT
Series
Accession:
GSE39200
ID:
200039200
15.

A Multi-loop, Double-cube Microarray Design Applied to Prostate Cancer Cell Lines with Variable Sensitivity to Histone Deacetylase Inhibitors

(Submitter supplied) Implementation of a complex design for a microarray experiment on resistance mechanisms of histone deacetylase inhibitors (HDACI).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
22 Samples
Download data: TXT
Series
Accession:
GSE34452
ID:
200034452
16.

Profiling of THP-1 cells infected with H37Rv (wild-type), ∆E (deletion mutant of PknE), C∆E (complemented ∆E)

(Submitter supplied) Goal was to determine cellular changes on global macrophage gene expression.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
6 Samples
Download data: PDF, TXT, XLS
Series
Accession:
GSE20026
ID:
200020026
17.

Human gastric cancer cell MKN45: MKN45-GFP control vs. highly metastatic sublines

(Submitter supplied) Gene expression profiles of in vitro selected highly metastatic MKN45-GFP sublines. The results were compared with MKN45-GFP control cell line to determine the metastasis associated genes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
4 Samples
Download data: TXT
Series
Accession:
GSE33570
ID:
200033570
18.

Basal-like Breast Cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival

(Submitter supplied) Breast cancer is a heterogeneous disease with known tumor subtypes. In order to gain insight into the underlying etiologies of these disease subtypes, we first classified tumors according to gene expression intrinsic subtype, and second, identified subtype associated tumor genomic DNA copy number alterations (CNA) using a novel method called SWITCHdna. Most tumor subtypes showed specific CNA with Basal-like breast cancers being the most distinct and associated with loss of RB1, BRCA1, 5q11-35, and showed the greatest overall genomic instability. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by genome tiling array; Genome variation profiling by SNP array
7 related Platforms
504 Samples
Download data
Series
Accession:
GSE10893
ID:
200010893
19.

Global gene expression analysis reveals a link between NDRG1 and vesicle transport.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL887 GPL1708
35 Samples
Download data: GPR
Series
Accession:
GSE33439
ID:
200033439
20.

NDRG1 siRNA and overexpression in breast cell lines

(Submitter supplied) N-myc downstream-regulated gene 1 (*NDRG1*) is induced by cellular stress such as hypoxia and DNA damage, and in humans, germ line mutations cause Charcot-Marie-Tooth disease. However, the roles of NDRG1 in the cell are not fully understood. Previously, NDRG1 was shown to mediate doxorubicin resistance under hypoxia, suggesting a role for NDRG1 in cell survival under these conditions. We found decreased apoptosis in doxorubicin-treated cells expressing NDRG1 shRNAs under normoxia, demonstrating a requirement for NDRG1 in apoptosis in breast epithelial cells under normal oxygen pressure. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
25 Samples
Download data: GPR, TXT
Series
Accession:
GSE33437
ID:
200033437
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