GEO DataSets

(Submitter supplied) Experiments compared uninfected ECV304 cells with ECV304 cells infected with HSV-2, and both were tested for differential genes by microarray with the goal of determining the effect of HSV-2 on gene expression in ECV304 cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL887

2 Samples

Download data: TXT

(Submitter supplied) Single - cell profiling of patient tumours and of mouse models is revealing that many cancers are constituted of communities of genetically and phenotypically distinct clonal lineages 1 - 12. A functional model of breast cancer heterogeneity revealed that clonal sub - populations proficient at generating circulating tumour cells were not equally capable of forming metastases at secondary sites 13. A combination of differential expression and focused in vitro and in vivo RNAi screens revealed candidate drivers of metastasis discriminating these clones, which were then evaluated in gene expression datasets from breast cancer patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5325 GPL1390 GPL887

6 Samples

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(Submitter supplied) Objectives: Therapies being safe, effective and not vulnerable to develop resistance are highly desirable to counteract bacterial infections. Host-directed therapeutics is an alternative to conventional antibiotics based on perturbing host pathways subverted by pathogens during their life cycle by the use of host-directed drugs to counteract microbial infections. This study sought to identify cellular genes and pathways differentially expressed during airways epithelial infection by nontypable Haemophilus influenzae (NTHi). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL887

8 Samples

Download data: GPR

(Submitter supplied) To evaluate the expression of genes associated with MYCN in NB, 10 tumors with MYCN amplification and 10 with normal MYCN copy number were subjected to oligonucleotide microarray using Agilent oligo microarray chips.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL887

20 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL887 GPL570

63 Samples

Download data: CEL, TXT

(Submitter supplied) Adrenocortical carcinoma (ACC) is an aggressive endocrine tumor with a poor 5 year survival rate of 10-20%. We used expression profiling to assess the transcriptional changes associated with ACC as compared to normal adrenal glands with the goal of identifying new targets for treatment. Fourteen ACC tumors were profiled on both Affymetrix U133 Plus 2 or Agilent 22K Human Genome arrays; an additional six tumors were profiled on one or the other array. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL887

15 Samples

Download data: TXT

(Submitter supplied) Introduction: In breast cancers, the basal-like subtype has high levels of genomic instability relative to other breast cancer subtypes with many basal-like-specific regions of aberration. There is evidence that this genomic instability extends to smaller scale genomic aberrations as well, as shown by a previously described micro-event in the PTEN gene in the Basal-like SUM149 breast cancer cell line. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array; Genome variation profiling by genome tiling array

8 related Platforms

192 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL7260 GPL887 GPL7264

88 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of human lymphoblastoid cell lines with different ATM genotypes at basal level was compared to extract gene expression signatures that can identify ataxia telangiectasia (AT) carries from non AT carries and AT patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL887

24 Samples

Download data: TXT

(Submitter supplied) Purpose:The Vimentin gene plays a pivotal role in epithelial-to-mesenchymal transition (EMT) and is known to be over-expressed in the prognostically poor basal-like breast cancer subtype. Recent studies have reported Vimentin DNA methylation in association with poor clinical outcomes in other solid tumors, but not in breast cancer. We therefore quantified Vimentin DNA methylation in breast tumors and matched normal pairs in association with gene expression and survival in a cohort of 83 breast cancer patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5325 GPL1390 GPL887

83 Samples

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(Submitter supplied) Chemotherapy resistance frequently drives tumor progression. However, the underlying molecular mechanisms are poorly characterized. Epithelial-to-mesenchymal transition (EMT) has been shown to correlate with therapy resistance, but the functional link and signaling pathways remain to be elucidated. We report here that miR-30c, a human breast tumor prognostic marker, plays a pivotal role in chemo-resistance by a direct targeting of the actin-transporter TWF1, which promotes EMT. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

6 related Platforms

60 Samples

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(Submitter supplied) We aimed to find clinically relevant gene activities ruled by the signal transducer and activator of transcription 3 (STAT3) proteins in an ER(-) breast cancer population via network approach. STAT3 is negatively associated with both lymph nodal category and stage. MYC is a component of STAT3 network. MYC and STAT3 may co-regulate gene expressions for Warburg effect, stem cell like phenotype, cell proliferation and angiogenesis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL887

102 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL4133 GPL887

40 Samples

Download data: TXT

(Submitter supplied) The NS1 protein of influenza virus counters host antiviral defences primarily by antagonizing the type I interferon (IFN) response. Both the N-terminal dsRNA-binding domain and the C-terminal effector domain are required for optimal suppression of host responses during infection. To better understand the regulatory role of the NS1 effector domain, we used an NS1-truncated mutant virus derived from human H1N1 influenza isolate A/Texas/36/91 (Tx/91) and assessed global transcriptional profiles from two independent human lung cell-culture models.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL887 GPL4133

32 Samples

Download data: TXT

(Submitter supplied) Implementation of a complex design for a microarray experiment on resistance mechanisms of histone deacetylase inhibitors (HDACI).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL887

22 Samples

Download data: TXT

(Submitter supplied) Goal was to determine cellular changes on global macrophage gene expression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL887

6 Samples

Download data: PDF, TXT, XLS

(Submitter supplied) Gene expression profiles of in vitro selected highly metastatic MKN45-GFP sublines. The results were compared with MKN45-GFP control cell line to determine the metastasis associated genes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL887

4 Samples

Download data: TXT

(Submitter supplied) Breast cancer is a heterogeneous disease with known tumor subtypes. In order to gain insight into the underlying etiologies of these disease subtypes, we first classified tumors according to gene expression intrinsic subtype, and second, identified subtype associated tumor genomic DNA copy number alterations (CNA) using a novel method called SWITCHdna. Most tumor subtypes showed specific CNA with Basal-like breast cancers being the most distinct and associated with loss of RB1, BRCA1, 5q11-35, and showed the greatest overall genomic instability. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array; Genome variation profiling by SNP array

7 related Platforms

504 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL887 GPL1708

35 Samples

Download data: GPR

(Submitter supplied) N-myc downstream-regulated gene 1 (*NDRG1*) is induced by cellular stress such as hypoxia and DNA damage, and in humans, germ line mutations cause Charcot-Marie-Tooth disease. However, the roles of NDRG1 in the cell are not fully understood. Previously, NDRG1 was shown to mediate doxorubicin resistance under hypoxia, suggesting a role for NDRG1 in cell survival under these conditions. We found decreased apoptosis in doxorubicin-treated cells expressing NDRG1 shRNAs under normoxia, demonstrating a requirement for NDRG1 in apoptosis in breast epithelial cells under normal oxygen pressure. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL887

25 Samples

Download data: GPR, TXT