GPL9052[Accession] - GEO DataSets

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Select item 2002102021.

Loss of Feedback Regulation between FAM3B and Androgen Receptor Driving Prostate Cancer Progression

(Submitter supplied) TMPRSS2-ERG gene fusion is one of the most frequent genetic alterations in prostate cancer (PC). Through a systematical survey of the loss of interstitial genes and patient outcomes, we nominated FAM3B as the top-ranked interstitial genes whose loss is associated with a poor prognosis. Using cultured cells, patient- and cell-line-derived xenograft models in gonad-intact or castrated host, and genetically engineered mouse models with FAM3B overexpression, knockdown, or knockout, we defined a driver role of FAM3B loss in prostate cancer progression. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL9052 GPL29480
12 Samples

Download data: TXT

Series

Accession:: GSE210202

ID:: 200210202

Select item 2002247542.

Distinct roles of the two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA Pol II transcription elongation [RNA-seq 2]

(Submitter supplied) The P-TEFb-containing super elongation complex (SEC) plays the essential role in transcriptional elongation control. The AF4/FMR2 family members AFF1 and AFF4 are the central scaffold proteins of SEC, associated with different human diseases. However, their specific roles in transcriptional control remain unclear. Here, we report that AFF1 and AFF4 show distinct genomic distribution patterns around TSS. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9052
8 Samples

Download data: BW

Series

Accession:: GSE224754

ID:: 200224754

Analyze with GEO2R

Select item 2002078133.

Distinct roles of the two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA Pol II transcription elongation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL9052
31 Samples

Download data: BW

Series

Accession:: GSE207813

ID:: 200207813

Select item 2002078124.

Distinct roles of the two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA Pol II transcription elongation [RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9052
4 Samples

Download data: BW

Series

Accession:: GSE207812

ID:: 200207812

Analyze with GEO2R

Select item 2002059805.

Inverse Agonists of the Androgen Receptor

(Submitter supplied) We report the efficacy of androgen receptor inverse agonists (ARIAs) in altering androgen receptor (AR) transcriptional activity. Through RNA-sequencing studies in a panel of prostate cancer cell lines and patient derived xenograft models, we demonstrate ARIAs succcessfully inhibit androgen response gene sets. ChIP-seq and CUT&RUN studies demonstrate H3K27ac decreases at AR-target genes in response to treatment. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL24676 GPL10999 GPL9052
57 Samples

Download data: BED, HIC, TXT

Series

Accession:: GSE205980

ID:: 200205980

Analyze with GEO2R

Select item 2001802996.

Functional analysis QSER1

(Submitter supplied) In this study, we found that QSER1 is a generic anti-apoptosis factor suppressing the p53 target apoptotic genes irrespective of p53 status.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
5 Samples

Download data: BW

Series

Accession:: GSE180299

ID:: 200180299

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001605347.

CDK7 is Essential for Sustained Expression of the Condensin Complex, Chromatin Compaction, and Maintenance of Chromosomal Stability

(Submitter supplied) Identifying a mechanism by which CDK7 inhibition promotes genomic stability in TNBC

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL9052
15 Samples

Download data: TXT, WIG

Series

Accession:: GSE160534

ID:: 200160534

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2002185598.

Tagmentation (CUT&Tag) assay for ATF4 in HCT116 (Human colorectal cancer) cells

(Submitter supplied) To determine the biological function of ATF4 in the modulation of downstream target genes, we performed Tagmentation (CUT&Tag) assay in HCT 116 (Human colorectal cancer) cells

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
1 Sample

Download data: BW

Series

Accession:: GSE218559

ID:: 200218559

Select item 2000850949.

RNA-seq profiling of forced expression of FoxF2 in Benign Prostate Hyperplasia

(Submitter supplied) Since the first forkhead transcription factor was identified, its family members have been implicated in a variety of cellular processes, including embryonic development and disease. The purpose of this experiment was to help understand the role of a transcriptional factor Foxf1 in human benign prostatic hyperplasia.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9052
6 Samples

Download data: TXT

Series

Accession:: GSE85094

ID:: 200085094

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20020267010.

Epigenetic reprogramming of Kaposi’s sarcoma-associated herpesvirus during hypoxic reactivation

(Submitter supplied) Chromatin Immuno-precipitaion sequencing was performed using H3-Ac, H3K4Me3, H3K9Me3, H3K27Me3, LANA, RTA and DNA Polymerase 1 alpha antibodies to investigate its enrichment on Kaposi's sarcoma associated herpesvirus (KSHV) genome in BC3 cells under normoxic or hypoxic conditions

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
14 Samples

Download data: CSV, TXT, XLS

Series

Accession:: GSE202670

ID:: 200202670

PubMed Full text in PMC Similar studies

Select item 20020946011.

Control ChIP-seq from keratinocyte (ENCSR678FZH)

(Submitter supplied) NHEK For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
2 Samples

Download data: TXT

Series

Accession:: GSE209460

ID:: 200209460

PubMed Full text in PMC Similar studies ENCODE

Select item 20020897312.

Control ChIP-seq from GM12878 (ENCSR356PFJ)

(Submitter supplied) For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
2 Samples

Download data: TXT

Series

Accession:: GSE208973

ID:: 200208973

PubMed Full text in PMC Similar studies ENCODE

Select item 20020881713.

Control ChIP-seq from H1 (ENCSR704AQC)

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
2 Samples

Download data: TXT

Series

Accession:: GSE208817

ID:: 200208817

PubMed Full text in PMC Similar studies ENCODE

Select item 20018992714.

Differential Expression of Calcium Channels and Signaling Pathways in Hematologic Cancers

(Submitter supplied) Cell surface calcium (Ca2+) channels permit Ca2+ ion influx, with Ca2+ taking part in cellular functions such as proliferation, survival, and activation. The expression of voltage-dependent Ca2+ (CaV) channels may modulate the growth of hematologic cancers. Profile analysis of Ca2+ channels, with a focus on the L-type CaV channels, was performed on RNA sequencing data from lymphoma and leukemia cell lines and samples derived from patients with diffuse large B cell lymphoma (DLBCL). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL15520 GPL9052
44 Samples

Download data: TXT

Series

Accession:: GSE189927

ID:: 200189927

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20019824315.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
8 Samples

Download data: BW, XLS, XLSX

Series

Accession:: GSE198243

ID:: 200198243

Select item 20019824216.

(Submitter supplied) Endocrine therapy is the preferred therapeutic strategy for estrogen receptor alpha (ERa)-positive breast cancer, but intrinsic endocrine resistance leads a significant challenge. CCCTC binding factor (CTCF)-mediated hyperactivation of ERa-associated enhancers have been recognized as important molecular mechanism leading to endocrine resistance, yet the underlying molecular mechanism of this process still remains unclear. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
4 Samples

Download data: BW, XLS

Series

Accession:: GSE198242

ID:: 200198242

Select item 20019824117.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
4 Samples

Download data: BW, XLSX

Series

Accession:: GSE198241

ID:: 200198241

Select item 20019058718.

Targeting refractory mantle cell lymphoma for imaging and therapy using C-X-C chemokine receptor type 4 radioligands

(Submitter supplied) CXCR4 is widely expressed in hematological malignancies, including MCL The Cancer Cell Line Encyclopedia (CCLE) showed relatively high levels of CXCR4 mRNA in hematological malignancies but had no MCL cell lines within its collection. To better assess the suitability of targeting CXCR4 in MCL, we screened 11 MCL cell lines for CXCR4 mRNA expression (Cancer Research Centre, CRC). For comparison, we profiled other lymphoma subtypes, including Burkitt (n=3), activated B cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) (n=6), and germinal center B cell-like (GBC) DLBCL (n=14). more...