GEO DataSets

(Submitter supplied) The incidence of prostate cancer is frequent, occurring in almost one-third of men older than 45 years. Only a fraction of the cases reach the stages displaying clinical significance. Despite the advances in our understanding of prostate carcinogenesis and disease progression, our knowledge of this disease is still fragmented. Identification of the genes and patterns of gene expression will provide a more cohesive picture of prostate cancer biology. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

4 related Platforms

444 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) FCHL is a common, complex genetic lipid disorder with a largely unknown aetiology. Altered adipose tissue metabolism has been implicated as contributing to FCHL. We used microarrays to investigate the mRNA profiles of FCHL patients with CHD and non-FCHL patients with CHD in comparison with non-FCHL, non-CHD patients to define a core set of genes that were differentially expressed in FCHL and to provide a reasonable launch-pad for examining the direct contribution of one of this gene set to the development of adipose tissue.

Organism:

Homo sapiens

Type:

Expression profiling by array

6 related Platforms

120 Samples

Download data: CEL

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel Keywords: cell_type_comparison_design; disease state; cell line; tissue type

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

300 Samples

Download data: CEL, EXP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2545 GDS2546 GDS2547

Platforms:

GPL93 GPL92 GPL8300

504 Samples

Download data: CEL

Analysis of metastatic prostate tumors and primary prostate tumors. Normal tissue adjacent to the tumor and normal donor tissue also examined. Metastasis reflects the most adverse clinical outcome. Results provide insight into the molecular mechanisms underlying the metastatic process.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 tissue sets

Platform:

GPL92

Series:

GSE6919

167 Samples

Download data: CEL

(Submitter supplied) Prostate cancer is characterized by heterogeneity in the clinical course that often does not to correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can reliably predict which patients are at higher risk of developing metastatic disease. Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL93 GPL8300 GPL92

181 Samples

Download data: CEL

(Submitter supplied) Prostate cancer is characterized by heterogeneity in the clinical course that often does not to correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can reliably predict which patients are at higher risk of developing metastatic disease. Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL93 GPL8300 GPL92

196 Samples

Download data: CEL

(Submitter supplied) Prostate cancer is characterized by heterogeneity in the clinical course that often does not to correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can reliably predict which patients are at higher risk of developing metastatic disease. Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL92 GPL8300 GPL93

75 Samples

Download data: CEL

(Submitter supplied) Prostate cancer is characterized by heterogeneity in the clinical course that often does not to correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can reliably predict which patients are at higher risk of developing metastatic disease. Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL8300 GPL92 GPL93

52 Samples

Download data: CEL

(Submitter supplied) Microarray analysis comparing gene expression profiles of adipocytes from non-diabetic lean vs non-diabetic obese Pima Indian subjects to identify differentially expressed adipocyte genes with obesity. RNA samples of isolated abdominal subcutaneous adipocytes from 20 lean (10 Males / 10 Females, aged 31±6 year, Body Mass Index 25±3 kg/m2 ) and 19 obese (9M/10F, 29±5y, 55±8 kg/m2 ) subjects were hybridized individually to Affymetrix oligonucleotide arrays HG-U95A, B, C, D, and E. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS1495 GDS1496 GDS1497 GDS1498 GDS3601 GDS3602

6 related Platforms

195 Samples

Download data

Analysis of cultured abdominal subcutaneous mature adipocytes from 9 male and 10 female non-diabetic obese Pima Indians. The prevalence of obesity in Pima Indians is among the highest of any population. Results provide insight into the role of adipocytes in obesity and obesity-related inflammation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 gender sets

Platform:

GPL92

Series:

GSE2508

39 Samples

Download data

(Submitter supplied) The experiment design was multifold, consisting of a time course experiment on LNCaP C4-2 human prostate adenocarcinoma cells following irradiation to a dose of 10 Sv from a Cesium-137 mixed gamma and beta source, with two additional samples, one exposed to radiation in four fractions instead of all at once, and one containing the parent LNCaP cell line. PolyA+ RNA was extracted, processed and hybridized to the Affymetrix (Santa Clara, CA, www.affymetrix.com) HGU-95 (Av1-E) chip sets, and then washed, stained and scanned according to Affymetrix's protocols contained in the GeneChip(R) Expression Analysis Manual. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS719 GDS720 GDS721 GDS722 GDS723

5 related Platforms

25 Samples

Download data

Time course of androgen-independent LNCaP C4-2 prostate adenocarcinoma cells following ionizing radiation (IR) to a dose of 10 Sv. Cells harvested 6 or 24 hours after IR. Dose applied in 1 or 4 fractions.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell line, 3 dose, 3 time sets

Platform:

GPL92

Series:

GSE762

5 Samples

Download data

(Submitter supplied) Primary cultures of human trophoblasts were established from normal, term placenta. Cells were treated five hours after plating. This sample was treated with 1 uM GW7845. RNA was extracted after 48 hours of treatment using Tri-reagent. Each sample was pooled from three individual placentas prior to target generation. Targets were produced using standard Affymetrix procedures from 30ug of total RNA. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

75 Samples

Download data

(Submitter supplied) molecular profiles (HG-U95B,C,D,E) of biopsy skeletal muscle samples obtained from 10 normal individuals and 10 DMD patients Keywords = gene expression profiles of normal human skeletal muscles Keywords = gene expression profiles of DMD patients' skelatal muscle samples Keywords = Affymetrix HG-U95B Keywords = Affymetrix HG-U95C Keywords = Affymetrix HG-U95D Keywords = Affymetrix HG-U95E Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS609 GDS610 GDS611 GDS612

4 related Platforms

86 Samples

Download data: CEL, EXP, RPT

Search for modifying factors and pathogenic pathways involved in Duchenne muscular dystrophy (DMD). Quadricep skeletal muscle biopsies from DMD patients and unaffected control patients examined.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL92

Series:

GSE1007

21 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) Normal human tissue expression profiling Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS422 GDS423 GDS424 GDS425 GDS426

5 related Platforms

120 Samples

Download data

Analysis of gene expression in a variety of normal tissues. Samples typically composed of a pool of 10-25 individuals. Included as part of the GeneNote project.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 12 tissue sets

Platform:

GPL92

Series:

GSE803

24 Samples

Download data

(Submitter supplied) Non-union skeletal fractures are characterized by their inability to heal six months after injury. Left untreated, the non-union fracture may cause advanced arthritis or loss of function in the affected limb. Arrays were used to identify the mechanisms that lead to lack of skeletal repair in non-unions. These profiles are the non-union callous samples pooled from five individuals Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS367 GDS368 GDS369

Platforms:

GPL92 GPL93 GPL8300

12 Samples

Download data: CEL

(Submitter supplied) This is a large series human Duchenne muscular dystrophy patient muscle biopsies, in specific age groups, using all available Affymetrix arrays (including a custom MuscleChip produced by the Hoffman lab). Both mixed groups of patients (5 patient biopsies per group) and individual biopsies were done. Hypothesis: That the progression of DMD can be understood in terms of muscle molecular remodeling. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS214 GDS262 GDS264 GDS265 GDS270

7 related Platforms

57 Samples

Download data: CEL