GEO DataSets

(Submitter supplied) We aimed at finding differently expressed genes in whole blood cells of African children with asymptomatic Plasmodium falciparum infection (A), uncomplicated malaria (U), severe malarial anemia (A) and cerebral malaria (Ce) compared one to another and to healthy children (Co). Understanding malarial immunopathology in the human host represents and enormous challenge for transcriptomic research. In this work, we used microarray and real-time RT-PCR technology to pursue deeper knowledge about the mechanisms underlying this disease in African children. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

47 Samples

Download data: CEL, CHP

(Submitter supplied) This microarray analysis identified differentially regulated expression of 326 genes (p value=<0.05 and fold change of +/-2). Based on these genes, a biological LH network was generated consisting molecules where the significance of the association was measured by Fisher's exact test. We used microarray gene expression analysis to dissect the LH-induced gene expression in the ovaries of PCOS women.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

36 Samples

Download data: CEL

(Submitter supplied) Human embryonic stem cells (hESCs) display a unique ability to self-renew in culture while retaining the potential to form the full repertoire of cell types found in the body. A complex molecular network underlies the maintenance of this pluripotent state. We used microarrays to identify genes that are highly expressed in pluripotent hESCs, but are consequently down-regulated upon differentiation in the presence of retinoic acid.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

52 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

4 related Platforms

75 Samples

Download data: BED, CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96 GPL570

316 Samples

Download data: CEL

(Submitter supplied) Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in children and younger adults. The purpose of this study was the genetic and clinical characterization of Ph-like ALL in adults. Among 207 adult B-cell precursor ALL patients, 26 (13%) were classified as Ph-like using Affymetrix microarrays. The incidence of this subtype was 25% among 105 B-cell precursor ALL patients negative for BCR-ABL1 and MLL-translocations (B-other). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL97

109 Samples

Download data: CEL

(Submitter supplied) To determine if oligonucleotide arrays can be used to identify BRCA1 positive mutation carriers and to gain further insight into the role of BRCA1.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

83 Samples

Download data: CEL

(Submitter supplied) Gene expression analysis was conducted using a GeneChip® Human Genome U133(HG–U133A & B) array with more than 39,000 transcripts Cytokines, growth factors, and their receptors are known to play important roles in cell survival, proliferation, differentiation and immune response in normal and cancer cells. Substantial evidence indicates that deregulation of growth factor and cytokine signaling contributes to leukemogenesis through aberrant activation of kinase-driven signaling pathways. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

279 Samples

Download data: CEL

(Submitter supplied) Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration as a result of abnormal neuronal loss. To elucidate the molecular systems associated with AD, we characterized the gene expression changes associated with multiple clinical and neuropathological traits in 1,053 postmortem brain samples across 19 brain regions from 125 persons dying with varying severities of dementia and variable AD-neuropathology severities.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL570 GPL97 GPL96

2004 Samples

Download data: CEL

(Submitter supplied) Migrated from 1.6 id: 1015897590491013 GEDP id: 760 In current clinical practice, histology-based grading of diffuse infiltrative gliomas is the best predictor of patient survival time. Yet histology provides little insight into the underlying biology of gliomas and is limited in its ability to identify and guide new molecularly targeted therapies. We have performed large-scale gene expression analysis using the Affymetrix HG U133 oligonucleotide arrays on 85 diffuse infiltrating gliomas of all histologic types to assess whether a gene expression-based, histology-independent classifier is predictive of survival and to determine whether gene expression signatures provide insight into the biology of gliomas. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

170 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) breast cancer

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

516 Samples

Download data: CEL, XLS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

20 Samples

Download data: CEL

(Submitter supplied) Fragmented RNA cocktails from FACS sorted Human decidual NK cell, and peripheral blood CD56Bright and CD56Dim NK cells, previously hybridization to HGU95AV2 chips (Koopman et al J Exp Med. 2003 Oct 20;198(8):1201-1), were stored long term at -80C, thawed and hybridized to HG-U133B arrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL97

10 Samples

Download data: CEL

(Submitter supplied) Genome wide expression profiling was used to detect cases of adult T-ALL lacking GATA3 expression. GATA3low T-ALL exhibited enrichment of myeloid/lymphoid progenitor (MLP) and granulocyte/monocyte progenitor (GMP) genes, while T-cell specific signatures were downregulated. Among upregulated genes FLT3 was identified and mutational analyses revealed a high rate of FLT3 mutations.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL570 GPL96

127 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

114 Samples

Download data: CEL

(Submitter supplied) To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. We then validated the identified genes using data obtained by different groups. The 33-gene signature was able to classify 87% of hepatic metastases, 98% of primary tumors, 97% of normal colon mucosa, and 95% of normal liver tissues in six datasets obtained using five different microarray platforms. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL97

57 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

142 Samples

Download data: CEL

(Submitter supplied) To explore the full extent of IFN-regulated transcriptional changes, we exposed monocytes from two healthy donors to recombinant type I IFN (IFN-α2b) in vitro. RNA was extracted at 6 hrs and the expression data was normalized to that of monocytes cultured with medium.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

4 Samples

Download data: CEL

(Submitter supplied) Monocytes from 3 healthy donors were cultured for 6 hours in the presence of 20% serum from three newly diagnosed, untreated SLE patients. Microarray analysis was then performed upon normalizing the gene expression levels of samples incubated with SLE sera to those incubated with autologous serum.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

12 Samples

Download data: CEL

(Submitter supplied) We screened SLE monocytes from 19 SLE patients and selected 4 that induced CD4+ T cell proliferation in vitro and 4 that did not. CFSE labeled CD4-T cells (105) were incubated with SLE monocytes (2 x 104). Cells were harvested at 6 hours for RNA extraction.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

46 Samples

Download data: CEL