GSE125186[Accession] - GEO DataSets - NCBI

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Select item 2001251861.

Impaired Cell Fate by Gain-of-function Mutations in a Chromatin Reader

(Submitter supplied) We previously identified the YEATS domain-containing protein ENL as a reader of histone acetylation. Recently, hotspot mutations in ENL were frequently found in Wilms’ tumor, the most common type of pediatric kidney cancer. Here, we report that these cancer-associated mutations in the ENL YEATS domain confer gain of functions in transcriptional control and impair kidney differentiation by driving self-reinforced chromatin targeting. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21290 GPL18573
43 Samples

Download data: BW, TXT

Series

Accession:: GSE125186

ID:: 200125186

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 1000212902.

Illumina HiSeq 3000 (Homo sapiens)

Organism:: Homo sapiens

1066 Series
26807 Samples

Platform

Accession:: GPL21290

ID:: 100021290

Select item 1000185733.

Illumina NextSeq 500 (Homo sapiens)

Organism:: Homo sapiens

11857 Series
327747 Samples

Platform

Accession:: GPL18573

ID:: 100018573

Select item 3035647894.

ChIPSeq.CDK9_WT_ENL

Organism:: Homo sapiens

Source name:: HEK293

Platform:: GPL18573
Series:: GSE125186

Download data: BW

Sample

Accession:: GSM3564789

ID:: 303564789

SRA Run Selector

Select item 3035647885.

ChIPSeq.CDK9_T3_mut

Organism:: Homo sapiens

Source name:: HEK293

Platform:: GPL18573
Series:: GSE125186

Download data: BW

Sample

Accession:: GSM3564788

ID:: 303564788

SRA Run Selector

Select item 3035647876.

ChIPSeq.CDK9_T2_mut

Organism:: Homo sapiens

Source name:: HEK293

Platform:: GPL18573
Series:: GSE125186

Download data: BW

Sample

Accession:: GSM3564787

ID:: 303564787

SRA Run Selector

Select item 3035647867.

ChIPSeq.CDK9_T1_mut

Organism:: Homo sapiens

Source name:: HEK293

Platform:: GPL18573
Series:: GSE125186

Download data: BW

Sample

Accession:: GSM3564786

ID:: 303564786

SRA Run Selector

Select item 3035647858.

ChIPSeq.PolII_S2P_WT_ENL

Organism:: Homo sapiens

Source name:: HEK293

Platform:: GPL18573
Series:: GSE125186

Download data: BW

Sample

Accession:: GSM3564785

ID:: 303564785

SRA Run Selector

Select item 3035647849.

ChIPSeq.PolII_S2P_T3_mut

Organism:: Homo sapiens

Source name:: HEK293

Platform:: GPL18573
Series:: GSE125186

Download data: BW

Sample

Accession:: GSM3564784

ID:: 303564784

SRA Run Selector

Select item 30356478310.

ChIPSeq.PolII_S2P_T2_mut

Organism:: Homo sapiens

Source name:: HEK293

Platform:: GPL18573
Series:: GSE125186

Download data: BW

Sample

Accession:: GSM3564783

ID:: 303564783

SRA Run Selector

Select item 30356478211.

ChIPSeq.PolII_S2P_T1_mut

Organism:: Homo sapiens

Source name:: HEK293

Platform:: GPL18573
Series:: GSE125186

Download data: BW

Sample

Accession:: GSM3564782

ID:: 303564782

SRA Run Selector

Select item 30356482412.

RNASeq.HK2_ENL_T3_mut_C

Organism:: Homo sapiens

Source name:: HK-2

Platform:: GPL21290
Series:: GSE125186

Download data: TXT

Sample

Accession:: GSM3564824

ID:: 303564824

SRA Run Selector

Select item 30356482313.

RNASeq.HK2_ENL_T3_mut_A

Organism:: Homo sapiens

Source name:: HK-2

Platform:: GPL21290
Series:: GSE125186

Download data: TXT

Sample

Accession:: GSM3564823

ID:: 303564823

SRA Run Selector

Select item 30356482214.

RNASeq.HK2_ENL_T2_mut_B

Organism:: Homo sapiens

Source name:: HK-2

Platform:: GPL21290
Series:: GSE125186

Download data: TXT

Sample

Accession:: GSM3564822

ID:: 303564822

SRA Run Selector

Select item 30356482115.

RNASeq.HK2_ENL_T2_mut_A

Organism:: Homo sapiens

Source name:: HK-2

Platform:: GPL21290
Series:: GSE125186

Download data: TXT

Sample

Accession:: GSM3564821

ID:: 303564821

SRA Run Selector

Select item 30356482016.

RNASeq.HK2_ENL_T1_mut_B

Organism:: Homo sapiens

Source name:: HK-2

Platform:: GPL21290
Series:: GSE125186

Download data: TXT

Sample

Accession:: GSM3564820

ID:: 303564820

SRA Run Selector

Select item 30356481917.

RNASeq.HK2_ENL_T1_mut_A

Organism:: Homo sapiens

Source name:: HK-2

Platform:: GPL21290
Series:: GSE125186

Download data: TXT

Sample

Accession:: GSM3564819

ID:: 303564819

SRA Run Selector

Select item 30356481818.

RNASeq.HK2_WT_ENL_B

Organism:: Homo sapiens

Source name:: HK-2

Platform:: GPL21290
Series:: GSE125186

Download data: TXT

Sample

Accession:: GSM3564818

ID:: 303564818

SRA Run Selector

Select item 30356481719.

RNASeq.HK2_WT_ENL_A

Organism:: Homo sapiens

Source name:: HK-2

Platform:: GPL21290
Series:: GSE125186

Download data: TXT

Sample

Accession:: GSM3564817

ID:: 303564817

SRA Run Selector

Select item 30356481620.

RNASeq.HEK293_ENL_T3_mut_B

Organism:: Homo sapiens

Source name:: HEK293

Platform:: GPL21290
Series:: GSE125186

Download data: TXT

Sample

Accession:: GSM3564816

ID:: 303564816

SRA Run Selector

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