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1.

Peripheral blood mononuclear cells treated with a CDK inhibitor

(Submitter supplied) A genomics-based approach to identify pharmacodynamic biomarkers was used for a CDK (cyclin-dependent kinase) inhibitory drug. R547 is a potent CDK inhibitor with a potent anti-proliferative effect at pharmacologically relevant doses, and is currently in Phase I clinical trials. Utilizing preclinical data derived from microarray experiments, we identified pharmacodynamic biomarkers to test in blood samples from patients in clinical trials. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5266
Platform:
GPL570
37 Samples
Download data: CEL
Series
Accession:
GSE15389
ID:
200015389
2.
Full record GDS5266

Cyclin-dependent kinase inhibitor R547 effect on peripheral blood mononuclear cells: dose response and time course

Analysis of peripheral blood mononuclear cells treated with CDK inhibitor R547 at 2 doses for 2 and 24 hours. R547 exerts an antiproliferative effect on various cell lines. Results compared with those from DU145 (GDS5267) and HCT116 cells (GDS5268) to identify pharmacodynamic biomarkers for R547.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent, 3 dose, 3 time sets
Platform:
GPL570
Series:
GSE15389
37 Samples
Download data: CEL
DataSet
Accession:
GDS5266
ID:
5266
3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5504 Series
61 Related Platforms
165289 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570
4.

PBMCs vehicle treated for 2 hours,replicate 6

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 2 hours,replicate 6
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386261
ID:
300386261
5.

PBMCs vehicle treated for 2 hours,replicate 5

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 2 hours,replicate 5
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386260
ID:
300386260
6.

PBMCs vehicle treated for 2 hours,replicate 4

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 2 hours,replicate 4
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386259
ID:
300386259
7.

PBMCs vehicle treated for 2 hours,replicate 3

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 2 hours,replicate 3
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386258
ID:
300386258
8.

PBMCs vehicle treated for 2 hours,replicate 2

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 2 hours,replicate 2
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386257
ID:
300386257
9.

PBMCs vehicle treated for 2 hours,replicate 1

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 2 hours,replicate 1
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386256
ID:
300386256
10.

PBMCs vehicle treated for 24 hours,replicate 6

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 24 hours,replicate 6
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386255
ID:
300386255
11.

PBMCs vehicle treated for 24 hours,replicate 5

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 24 hours,replicate 5
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386254
ID:
300386254
12.

PBMCs vehicle treated for 24 hours,replicate 4

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 24 hours,replicate 4
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386253
ID:
300386253
13.

PBMCs vehicle treated for 24 hours,replicate 3

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 24 hours,replicate 3
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386252
ID:
300386252
14.

PBMCs vehicle treated for 24 hours,replicate 2

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 24 hours,replicate 2
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386251
ID:
300386251
15.

PBMCs vehicle treated for 24 hours,replicate 1

Organism:
Homo sapiens
Source name:
PBMCs vehicle treated for 24 hours,replicate 1
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386250
ID:
300386250
16.

Untreated PBMCs, replicate 3

Organism:
Homo sapiens
Source name:
Untreated PBMCs, replicate 3
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386249
ID:
300386249
17.

Untreated PBMCs, replicate 2

Organism:
Homo sapiens
Source name:
Untreated PBMCs, replicate 2
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386248
ID:
300386248
18.

Untreated PBMCs, replicate 1

Organism:
Homo sapiens
Source name:
Untreated PBMCs, replicate 1
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386247
ID:
300386247
19.

PBMCs treated at the IC90 for 2 hours,replicate 6

Organism:
Homo sapiens
Source name:
PBMCs treated at the IC90 for 2 hours,replicate 6
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386246
ID:
300386246
20.

PBMCs treated at the IC90 for 2 hours,replicate 5

Organism:
Homo sapiens
Source name:
PBMCs treated at the IC90 for 2 hours,replicate 5
Platform:
GPL570
Series:
GSE15389 GSE15396
Dataset:
GDS5266
Download data: CEL
Sample
Accession:
GSM386245
ID:
300386245
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