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Items: 12

1.

Torcetrapib induces aldosterone and cortisol production in an intracellular calcium-dependent mechanism

(Submitter supplied) ILLUMINATE (Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events), the phase 3 morbidity and mortality trial of torcetrapib, a cholesteryl ester transfer protein (CETP) inhibitor, identified previously undescribed changes in plasma levels of potassium, sodium, bicarbonate, and aldosterone. A key question after this trial is whether the failure of torcetrapib was a result of CETP inhibition or of some other pharmacology of the molecule. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3556
Platform:
GPL570
9 Samples
Download data: CEL
Series
Accession:
GSE15918
ID:
200015918
2.
Full record GDS3556

Torcetrapib effect on adrenal carcinoma cell line

Analysis of H295 adrenal carcinoma cells treated with torcetrapib, an anti-cholesterol drug. Adverse side effects of torcetrapib treatment include changes in blood pressure, potassium, sodium, and aldosterone. Results provide insight into the molecular basis of the off-target side effects.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent sets
Platform:
GPL570
Series:
GSE15918
9 Samples
Download data: CEL
DataSet
Accession:
GDS3556
ID:
3556
3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5472 Series
61 Related Platforms
163699 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570
4.

H295R_Group_C_Dose_100_TIMEPT1_033

Organism:
Homo sapiens
Source name:
H295R adrenocortical carcinoma cells
Platform:
GPL570
Series:
GSE15918
Dataset:
GDS3556
Download data: CEL
Sample
Accession:
GSM399580
ID:
300399580
5.

H295R_Group_C_Dose_100_TIMEPT1_032

Organism:
Homo sapiens
Source name:
H295R adrenocortical carcinoma cells
Platform:
GPL570
Series:
GSE15918
Dataset:
GDS3556
Download data: CEL
Sample
Accession:
GSM399579
ID:
300399579
6.

H295R_Group_C_Dose_100_TIMEPT1_031

Organism:
Homo sapiens
Source name:
H295R adrenocortical carcinoma cells
Platform:
GPL570
Series:
GSE15918
Dataset:
GDS3556
Download data: CEL
Sample
Accession:
GSM399578
ID:
300399578
7.

H295R_Group_B_Dose_100_TIMEPT1_009

Organism:
Homo sapiens
Source name:
H295R adrenocortical carcinoma cells
Platform:
GPL570
Series:
GSE15918
Dataset:
GDS3556
Download data: CEL
Sample
Accession:
GSM399577
ID:
300399577
8.

H295R_Group_B_Dose_100_TIMEPT1_008

Organism:
Homo sapiens
Source name:
H295R adrenocortical carcinoma cells
Platform:
GPL570
Series:
GSE15918
Dataset:
GDS3556
Download data: CEL
Sample
Accession:
GSM399576
ID:
300399576
9.

H295R_Group_B_Dose_100_TIMEPT1_007

Organism:
Homo sapiens
Source name:
H295R adrenocortical carcinoma cells
Platform:
GPL570
Series:
GSE15918
Dataset:
GDS3556
Download data: CEL
Sample
Accession:
GSM399575
ID:
300399575
10.

H295R_Group_A_Dose_NA_TIMEPT1_003

Organism:
Homo sapiens
Source name:
H295R adrenocortical carcinoma cells
Platform:
GPL570
Series:
GSE15918
Dataset:
GDS3556
Download data: CEL
Sample
Accession:
GSM399574
ID:
300399574
11.

H295R_Group_A_Dose_NA_TIMEPT1_002

Organism:
Homo sapiens
Source name:
H295R adrenocortical carcinoma cells
Platform:
GPL570
Series:
GSE15918
Dataset:
GDS3556
Download data: CEL
Sample
Accession:
GSM399573
ID:
300399573
12.

H295R_Group_A_Dose_NA_TIMEPT1_001

Organism:
Homo sapiens
Source name:
H295R adrenocortical carcinoma cells
Platform:
GPL570
Series:
GSE15918
Dataset:
GDS3556
Download data: CEL
Sample
Accession:
GSM399572
ID:
300399572
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