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Items: 9

1.

Gfi1 regulates survival and lineage commitment of hematopoietic precursors and prevents myeloproliferative diseases

(Submitter supplied) Hematopoietic stem cells (HSCs) and lymphoid-primed multi-potential progenitors (LMPPs) are able to initiate both lymphoid and myeloid differentiation. We show here that the transcriptional repressor Gfi1 (growth factor independence 1) implements a specific gene expression program in HSCs and LMPPs that is critical for their survival and lymphoid differentiation potential. We present evidence that Gfi1 is required to maintain expression of genes involved in lymphoid development such as Flt-3, IL7R, Ebf1, Rag1, CCR9 and Notch1 and controls myeloid lineage commitment by regulating expression of genes such as Hoxa9 or M-CSFR. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4204
Platform:
GPL339
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE20282
ID:
200020282
2.
Full record GDS4204

Growth factor independence 1 knockout effect on LSK hematopoietic stem bone marrow cells

Analysis of Lin-Sca1+ckit+Flt3- (LSKFlt3-) hematopoietic stem cells (HSC) depleted of growth factor independence 1 (Gfi1). Transcriptional repressor Gfi1 restricts HSC proliferation and is essential to self-renewal. Results provide insight into molecular mechanisms underlying Gfi1 effects in HSCs.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE20282
6 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS4204
ID:
4204
3.

[MOE430A] Affymetrix Mouse Expression 430A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html The GeneChip Mouse Genome 430A 2.0 Array is accessioned in GEO as GPL8321. June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Mouse Genome 430A Array is a single array representing approximately 14,000 well-characterized mouse genes that can be used to explore biology and disease processes. more...
Organism:
Mus musculus
142 DataSets
422 Series
2 Related Platforms
5316 Samples
Download data
Platform
Accession:
GPL339
ID:
100000339
4.

8 wt

Organism:
Mus musculus
Source name:
LSK cell from Gfi1 wildtype mice
Platform:
GPL339
Series:
GSE20282
Dataset:
GDS4204
Download data: CEL, CHP
Sample
Accession:
GSM508533
ID:
300508533
5.

7 wt

Organism:
Mus musculus
Source name:
LSK cell from Gfi1 wildtype mice
Platform:
GPL339
Series:
GSE20282
Dataset:
GDS4204
Download data: CEL, CHP
Sample
Accession:
GSM508532
ID:
300508532
6.

5 wt

Organism:
Mus musculus
Source name:
LSK cell from Gfi1 wildtype mice
Platform:
GPL339
Series:
GSE20282
Dataset:
GDS4204
Download data: CEL, CHP
Sample
Accession:
GSM508531
ID:
300508531
7.

8 Ko

Organism:
Mus musculus
Source name:
LSK cell from Gfi1 knockout mice
Platform:
GPL339
Series:
GSE20282
Dataset:
GDS4204
Download data: CEL, CHP
Sample
Accession:
GSM508530
ID:
300508530
8.

7 Ko

Organism:
Mus musculus
Source name:
LSK cell from Gfi1 knockout mice
Platform:
GPL339
Series:
GSE20282
Dataset:
GDS4204
Download data: CEL, CHP
Sample
Accession:
GSM508529
ID:
300508529
9.

5 Ko

Organism:
Mus musculus
Source name:
LSK cell from Gfi1 knockout mice
Platform:
GPL339
Series:
GSE20282
Dataset:
GDS4204
Download data: CEL, CHP
Sample
Accession:
GSM508528
ID:
300508528
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Supplemental Content

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