GEO DataSets

(Submitter supplied) Gene expression changes in the heart of MCH3-KO mouse (HDAC3 f/f, Muscle Creatine Kinase-Cre) versus control WT mouse (HDAC3 f/f). Histone deacetylases (HDACs) play important roles in cardiac development and function. We show here that mice deficient of HDAC3 in heart and skeletabl muscle are relatively normal on normal chow, but develop hypertrophic cardiomyopathy and heart failure that leads to death on high-fat diet. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4886

Platform:

GPL6246

8 Samples

Download data: CEL

Analysis of hearts of 6 week old mutants deleted for histone deacetylase 3 (HDAC3). HDAC3 deletion occurred 7 days after birth. These MCH3-KO mutants are viable on normal chow but a high fat diet is lethal. The results underscore the impact gene-diet interactions may have on cardiovascular health.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE31251

8 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Mus musculus

143 DataSets

2496 Series

28 Related Platforms

30138 Samples

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