GEO DataSets

(Submitter supplied) piRNAs are required to maintain germline integrity and fertility but their mechanism of action is poorly understood. Here we demonstrate that C. elegans piRNAs silence transcripts in trans through imperfectly complementary sites. We find that target silencing is independent of Piwi endonuclease activity or “slicing”. Instead, we show that piRNAs initiate a localized secondary endogenous small interfering RNA (endo-siRNA) response. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

9 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html Has 22625 entries and was indexed 30-Apr-2002. Sequence information used for the design of the C. elegans array was downloaded from the Sanger Center database on December 05, 2000 and from GenBank release 121. All sequences were functionally reannotated by Affymetrix for improved descriptions. more...

Organism:

Caenorhabditis elegans

29 DataSets

180 Series

5 Related Platforms

2411 Samples

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