GSE43186[Accession] - GEO DataSets

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Items: 6

Select item 2000431861.

Glucose Metabolism impacts the spatio-temporal onset and magnitude of HSC induction in vivo

(Submitter supplied) Many pathways regulating blood formation have been elucidated, yet how each coordinates with embryonic biophysiology to modulate the spatio-temporal production of hematopoietic stem cells (HSCs) is currently unresolved. Here, we report that glucose metabolism impacts the onset and magnitude of HSC induction in vivo. In zebrafish, transient elevations in physiological glucose levels elicited dose-dependent effects on HSC development, including enhanced runx1 expression and hematopoietic cluster formation in the Aorta-Gonad-Mesonephros (AGM) region; embryonic-to-adult transplantation studies confirmed glucose increased functional HSCs. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL1319
4 Samples

Download data: CEL

Series

Accession:: GSE43186

ID:: 200043186

Analyze with GEO2R

Select item 1000013192.

[Zebrafish] Affymetrix Zebrafish Genome Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html The Affymetrix GeneChip Zebrafish Genome Array can be used to study gene expression of over 14,900 Danio rerio transcripts. Sequence information for this array was selected from the following public data sources: RefSeq (July 2003), GenBank (release 136.0, June 2003), dbEST (July 2003), and UniGene (Build 54, June 2003). more...