GSE45867[Accession] - GEO DataSets - NCBI

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Select item 2000458671.

Effects of tocilizumab versus methotrexate therapy on gene expression profiles in the early rheumatoid arthrtis synovium

(Submitter supplied) Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease that is characterized by the presence of inflammatory cytokines, including interleukin-6 (IL-6). Here, we investigated the global molecular effects of Tocilizumab, an approved humanized anti-IL6 Receptor antibody, versus Methotrexate therapy, in synovial biopsy samples collected prospectively in early RA before and 12 weeks after administration of the drug. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS5068 GDS5069
Platform:: GPL570
40 Samples

Download data: CEL

Series

Accession:: GSE45867

ID:: 200045867

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 50692.

Full record GDS5069

Rheumatoid arthritic synovium response to methotrexate

Analysis of synovial biopsies from rheumatoid arthritis patients before and 12 weeks after the start of methotrexate (MTX) therapy. Results compared to those obtained from tocilizumab (TCZ) therapy (GDS5068) and provide insight into the differences in the mechanisms of action between TCZ and MTX.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 8 individual sets

Platform:: GPL570
Series:: GSE45867
16 Samples

Download data: CEL

DataSet

Accession:: GDS5069

ID:: 5069

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 50683.

Full record GDS5068

Rheumatoid arthritic synovium response to tocilizumab

Analysis of synovial biopsies from rheumatoid arthritis patients before and 12 weeks after the start of tocilizumab (TCZ) therapy. Results compared to those obtained from methotrexate (MTX) therapy (GDS5069) and provide insight into the differences in the mechanisms of action between TCZ and MTX.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 12 individual sets

Platform:: GPL570
Series:: GSE45867
24 Samples

Download data: CEL

DataSet

Accession:: GDS5068

ID:: 5068

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000005704.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:: Homo sapiens

602 DataSets
5642 Series
61 Related Platforms
171144 Samples

Platform

Accession:: GPL570

ID:: 100000570

Select item 3011169725.

Synovial tissue after to Methotrexate therapy, repl 8

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, 12 weeks after initiation of Methotrexate therapy (15 mg, q1w)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116972

ID:: 301116972

Select item 3011169716.

Synovial tissue prior to Methotrexate therapy, repl 8

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, in untreated patient with early rheumatoid arthritis (< 1 year disease duration)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116971

ID:: 301116971

Select item 3011169707.

Synovial tissue after to Methotrexate therapy, repl 7

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, 12 weeks after initiation of Methotrexate therapy (15 mg, q1w)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116970

ID:: 301116970

Select item 3011169698.

Synovial tissue prior to Methotrexate therapy, repl 7

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, in untreated patient with early rheumatoid arthritis (< 1 year disease duration)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116969

ID:: 301116969

Select item 3011169689.

Synovial tissue after to Methotrexate therapy, repl 6

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, 12 weeks after initiation of Methotrexate therapy (15 mg, q1w)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116968

ID:: 301116968

Select item 30111696710.

Synovial tissue prior to Methotrexate therapy, repl 6

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, in untreated patient with early rheumatoid arthritis (< 1 year disease duration)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116967

ID:: 301116967

Select item 30111696611.

Synovial tissue after to Methotrexate therapy, repl 5

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, 12 weeks after initiation of Methotrexate therapy (15 mg, q1w)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116966

ID:: 301116966

Select item 30111696512.

Synovial tissue prior to Methotrexate therapy, repl 5

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, in untreated patient with early rheumatoid arthritis (< 1 year disease duration)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116965

ID:: 301116965

Select item 30111696413.

Synovial tissue after to Methotrexate therapy, repl 4

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, 12 weeks after initiation of Methotrexate therapy (15 mg, q1w)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116964

ID:: 301116964

Select item 30111696314.

Synovial tissue prior to Methotrexate therapy, repl 4

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, in untreated patient with early rheumatoid arthritis (< 1 year disease duration)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116963

ID:: 301116963

Select item 30111696215.

Synovial tissue after to Methotrexate therapy, repl 3

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, 12 weeks after initiation of Methotrexate therapy (15 mg, q1w)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116962

ID:: 301116962

Select item 30111696116.

Synovial tissue prior to Methotrexate therapy, repl 3

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, in untreated patient with early rheumatoid arthritis (< 1 year disease duration)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116961

ID:: 301116961

Select item 30111696017.

Synovial tissue after to Methotrexate therapy, repl 2

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, 12 weeks after initiation of Methotrexate therapy (15 mg, q1w)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116960

ID:: 301116960

Select item 30111695918.

Synovial tissue prior to Methotrexate therapy, repl 2

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, in untreated patient with early rheumatoid arthritis (< 1 year disease duration)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116959

ID:: 301116959

Select item 30111695819.

Synovial tissue after to Methotrexate therapy, repl 1

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, 12 weeks after initiation of Methotrexate therapy (15 mg, q1w)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116958

ID:: 301116958

Select item 30111695720.

Synovial tissue prior to Methotrexate therapy, repl 1

Organism:: Homo sapiens

Source name:: Knee synovial biopsies, obtained by needle arthroscopy, in untreated patient with early rheumatoid arthritis (< 1 year disease duration)

Platform:: GPL570
Series:: GSE45867
Dataset:: GDS5069

Download data: CEL

Sample

Accession:: GSM1116957

ID:: 301116957

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