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Items: 20

1.

SIRT1 but not its increased expression is essential for lifespan extension in caloric restricted mice.

(Submitter supplied) The SIRT1 deacetylase is one of the best-studied potential mediators of some of the anti-aging effects of calorie restriction (CR); but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespan than wild type mice on an ad libitum diet. Here we report that median lifespan extension in CR heterozygote SIRT1+/- mice was identical (51%) to that observed in wild type mice but SIRT1+/- mice displayed a higher frequency of some certain pathologies. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
18 Samples
Download data: TXT
Series
Accession:
GSE46895
ID:
200046895
2.

Illumina MouseRef-8 v2.0 expression beadchip

(Submitter supplied) The MouseRef-8 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...
Organism:
Mus musculus
33 DataSets
881 Series
16514 Samples
Download data: BGX
Platform
Accession:
GPL6885
ID:
100006885
3.

Liver-Ad Lib- Homozygous knockout-replicate 4

Organism:
Mus musculus
Source name:
Liver-Ad Lib- Homozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139934
ID:
301139934
4.

Liver-Ad Lib-Wt-replcate 3

Organism:
Mus musculus
Source name:
Liver-Ad Lib-Wt
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139933
ID:
301139933
5.

Liver-Ad Lib-Wt-replcate 2

Organism:
Mus musculus
Source name:
Liver-Ad Lib-Wt
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139932
ID:
301139932
6.

Liver-Ad Lib- Heterozygous knockout-replicate 2

Organism:
Mus musculus
Source name:
Liver-Ad Lib- Heterozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139931
ID:
301139931
7.

Liver-Ad Lib- Homozygous knockout-replicate 3

Organism:
Mus musculus
Source name:
Liver-Ad Lib- Homozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139930
ID:
301139930
8.

Liver-Ad Lib-Wt-replcate 1

Organism:
Mus musculus
Source name:
Liver-Ad Lib-Wt
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139929
ID:
301139929
9.

Liver-Ad Lib- Homozygous knockout-replicate 2

Organism:
Mus musculus
Source name:
Liver-Ad Lib- Homozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139928
ID:
301139928
10.

Liver-Ad Lib- Heterozygous knockout-replicate 1

Organism:
Mus musculus
Source name:
Liver-Ad Lib- Heterozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139927
ID:
301139927
11.

Liver-Ad Lib- Homozygous knockout-replicate 1

Organism:
Mus musculus
Source name:
Liver-Ad Lib- Homozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139926
ID:
301139926
12.

Liver-Caloric Restriction- Heterozygous knockout-replicate 3

Organism:
Mus musculus
Source name:
Liver-Caloric Restriction- Heterozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139925
ID:
301139925
13.

Liver-Caloric Restriction- Heterozygous knockout-replicate 2

Organism:
Mus musculus
Source name:
Liver-Caloric Restriction- Heterozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139924
ID:
301139924
14.

Liver-Caloric Restriction- Wt-replcate 3

Organism:
Mus musculus
Source name:
Liver-Caloric Restriction- Wt
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139923
ID:
301139923
15.

Liver-Caloric Restriction- Heterozygous knockout-replicate 1

Organism:
Mus musculus
Source name:
Liver-Caloric Restriction- Heterozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139922
ID:
301139922
16.

Liver-Caloric Restriction- Homozygous knockout-replicate 3

Organism:
Mus musculus
Source name:
Liver-Caloric Restriction- Homozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139921
ID:
301139921
17.

Liver-Caloric Restriction- Homozygous knockout-replicate 2

Organism:
Mus musculus
Source name:
Liver-Caloric Restriction- Homozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139920
ID:
301139920
18.

Liver-Caloric Restriction- Homozygous knockout-replicate 1

Organism:
Mus musculus
Source name:
Liver-Caloric Restriction- Homozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139919
ID:
301139919
19.

Liver-Caloric Restriction- Wt-replcate 2

Organism:
Mus musculus
Source name:
Liver-Caloric Restriction- Wt
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139918
ID:
301139918
20.

Liver-Caloric Restriction- Wt-replcate 1

Organism:
Mus musculus
Source name:
Liver-Caloric Restriction- Wt
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139917
ID:
301139917
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