GEO DataSets

(Submitter supplied) Demonstration of reduced biological effects with a prototypic modified risk tobacco product. Towards a systems toxicology-based risk assessment, we investigated molecular perturbations accompanying histopathological changes in a 28-day rat inhalation study combining transcriptomics with classical histopathology, and demonstrated reduced biological activity of a prototypic modified risk tobacco product (pMRTP) in comparison to the reference research cigarette 3R4F. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS5061 GDS5062 GDS5063

Platform:

GPL1355

75 Samples

Download data: CEL

Analysis of left lung bronchi from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:

GPL1355

Series:

GSE50254

25 Samples

Download data: CEL

Analysis of left lung parenchyma from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:

GPL1355

Series:

GSE50254

25 Samples

Download data: CEL

Analysis of nasal epithelia from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:

GPL1355

Series:

GSE50254

25 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Rat Genome 230 2.0 Array is a powerful tool for toxicology, neurobiology, and other applications using rat as a model organism. more...

Organism:

Rattus norvegicus

107 DataSets

746 Series

13 Related Platforms

23030 Samples

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