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Items: 11

1.

Development of heart valves requires Gata4 expression in endothelial-derived cells

(Submitter supplied) Cardiac malformations due to aberrant development of the atrioventricular (AV) valves are among the most common forms of congenital heart disease. At localized swellings of extracellular matrix known as the endocardial cushions, the endothelial lining of the heart undergoes an epithelial to mesenchymal transition (EMT) to form mesenchymal progenitors of the AV valves. Further growth and differentiation of these mesenchymal precursors results in formation of portions of the atrial and ventricular septae, and generation of thin, pliable valves. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3663
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE5298
ID:
200005298
2.
Full record GDS3663

Zinc finger transcription factor Gata4 inactivation effect on endothelial-derived cells

Analysis of atrioventricular canals (AVC) from E9.5 hearts with endocardial-restricted Gata4 inactivation. The mutant endothelium failed to undergo epithelial-mesenchymal transition (EMT), resulting in hypocellular AV cushions. Results provide insight into the role of Gata4 in endocardial cell EMT.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5298
8 Samples
Download data: CEL
3.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4426 Series
40 Related Platforms
57683 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
4.

AVC_mutant_rep4

Organism:
Mus musculus
Source name:
Atrioventricular canal
Platform:
GPL1261
Series:
GSE5298
Dataset:
GDS3663
Download data: CEL
Sample
Accession:
GSM120071
ID:
300120071
5.

AVC_mutant_rep3

Organism:
Mus musculus
Source name:
Atrioventricular canal
Platform:
GPL1261
Series:
GSE5298
Dataset:
GDS3663
Download data: CEL
Sample
Accession:
GSM120070
ID:
300120070
6.

AVC_mutant_rep2

Organism:
Mus musculus
Source name:
Atrioventricular canal
Platform:
GPL1261
Series:
GSE5298
Dataset:
GDS3663
Download data: CEL
Sample
Accession:
GSM120069
ID:
300120069
7.

AVC_mutant_rep1

Organism:
Mus musculus
Source name:
Atrioventricular canal
Platform:
GPL1261
Series:
GSE5298
Dataset:
GDS3663
Download data: CEL
Sample
Accession:
GSM120068
ID:
300120068
8.

AVC_control_rep4

Organism:
Mus musculus
Source name:
Atrioventricular canal
Platform:
GPL1261
Series:
GSE5298
Dataset:
GDS3663
Download data: CEL
Sample
Accession:
GSM120067
ID:
300120067
9.

AVC_control_rep3

Organism:
Mus musculus
Source name:
Atrioventricular canal
Platform:
GPL1261
Series:
GSE5298
Dataset:
GDS3663
Download data: CEL
Sample
Accession:
GSM120066
ID:
300120066
10.

AVC_control_rep2

Organism:
Mus musculus
Source name:
Atrioventricular canal
Platform:
GPL1261
Series:
GSE5298
Dataset:
GDS3663
Download data: CEL
Sample
Accession:
GSM120065
ID:
300120065
11.

AVC_control_rep1

Organism:
Mus musculus
Source name:
Atrioventricular canal
Platform:
GPL1261
Series:
GSE5298
Dataset:
GDS3663
Download data: CEL
Sample
Accession:
GSM120064
ID:
300120064
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