GSE56452[Accession] - GEO DataSets - NCBI

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Items: 18

Select item 2000564521.

SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1beta

(Submitter supplied) Aging is the predominant risk factor for neurodegenerative diseases. One key phenotype as brain ages is the aberrant innate immune response characterized by proinflammation. However, the molecular mechanisms underlying aging-associated proinflammation are poorly defined. Whether chronic inflammation plays a causal role in cognitive decline in aging and neurodegeneration has not been established. Here we established a mechanistic link between chronic inflammation and aging microglia, and demonstrated a causal role of aging microglia in neurodegenerative cognitive deficits. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
16 Samples

Download data: TXT

Series

Accession:: GSE56452

ID:: 200056452

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000068852.

Illumina MouseRef-8 v2.0 expression beadchip

(Submitter supplied) The MouseRef-8 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...

Organism:: Mus musculus

33 DataSets
902 Series
16886 Samples

Download data: BGX

Platform

Accession:: GPL6885

ID:: 100006885

Select item 3013617443.

Organism:: Mus musculus

Source name:: TAU/LysM

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361744

ID:: 301361744

Select item 3013617434.

Organism:: Mus musculus

Source name:: TAU/LysM

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361743

ID:: 301361743

Select item 3013617425.

Organism:: Mus musculus

Source name:: TAU

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361742

ID:: 301361742

Select item 3013617416.

Organism:: Mus musculus

Source name:: TAU

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361741

ID:: 301361741

Select item 3013617407.

Organism:: Mus musculus

Source name:: LysM old

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361740

ID:: 301361740

Select item 3013617398.

Organism:: Mus musculus

Source name:: LysM old

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361739

ID:: 301361739

Select item 3013617389.

Organism:: Mus musculus

Source name:: LysM old

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361738

ID:: 301361738

Select item 30136173710.

Organism:: Mus musculus

Source name:: SIRT1 old

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361737

ID:: 301361737

Select item 30136173611.

Organism:: Mus musculus

Source name:: SIRT1 old

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361736

ID:: 301361736

Select item 30136173512.

Organism:: Mus musculus

Source name:: SIRT1 old

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361735

ID:: 301361735

Select item 30136173413.

Organism:: Mus musculus

Source name:: LysM young

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361734

ID:: 301361734

Select item 30136173314.

Organism:: Mus musculus

Source name:: LysM young

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361733

ID:: 301361733

Select item 30136173215.

Organism:: Mus musculus

Source name:: LysM young

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361732

ID:: 301361732

Select item 30136173116.

Organism:: Mus musculus

Source name:: SIRT1 young

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361731

ID:: 301361731

Select item 30136173017.

Organism:: Mus musculus

Source name:: SIRT1 young

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361730

ID:: 301361730

Select item 30136172918.

Organism:: Mus musculus

Source name:: SIRT1 young

Platform:: GPL6885
Series:: GSE56452

Sample

Accession:: GSM1361729

ID:: 301361729

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