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Items: 10

1.

REDD1 (regulated in development and DNA damage response 1) dissociates therapeutic and adverse effects of topical steroids in skin

(Submitter supplied) Even though cutaneous atrophy is the major adverse effect of topical glucocorticoids, its molecular mechanisms are poorly understood. We found that glucocorticoids strongly increased the expression of REDD1 (regulated in development and DNA damage response 1), a stress-inducible inhibitor of mTOR, in mouse and human epidermis. We found that REDD1 knockout animals are partially resistant to glucocorticoid-induced epidermal and subcutaneous adipose atrophy which correlated with the protection of CD34+ follicular epithelial stem cells as well as p63+ keratinocyte progenitors in REDD1 knockout epidermis during chronic steroid treatment. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE59151
ID:
200059151
2.

Illumina MouseRef-8 v2.0 expression beadchip

(Submitter supplied) The MouseRef-8 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...
Organism:
Mus musculus
33 DataSets
881 Series
16514 Samples
Download data: BGX
Platform
Accession:
GPL6885
ID:
100006885
3.

epidermis_REDD1_KO_treated_FA_2

Organism:
Mus musculus
Source name:
Epidermis from posterior ear lobe
Platform:
GPL6885
Series:
GSE59151
Download data
Sample
Accession:
GSM1429436
ID:
301429436
4.

epidermis_REDD1_KO_treated_FA_1

Organism:
Mus musculus
Source name:
Epidermis from posterior ear lobe
Platform:
GPL6885
Series:
GSE59151
Download data
Sample
Accession:
GSM1429435
ID:
301429435
5.

epidermis_REDD1_KO_2

Organism:
Mus musculus
Source name:
Epidermis from posterior ear lobe
Platform:
GPL6885
Series:
GSE59151
Download data
Sample
Accession:
GSM1429434
ID:
301429434
6.

epidermis_REDD1_KO_1

Organism:
Mus musculus
Source name:
Epidermis from posterior ear lobe
Platform:
GPL6885
Series:
GSE59151
Download data
Sample
Accession:
GSM1429433
ID:
301429433
7.

epidermis_wildtype_treated_FA_2

Organism:
Mus musculus
Source name:
Epidermis from posterior ear lobe
Platform:
GPL6885
Series:
GSE59151
Download data
Sample
Accession:
GSM1429432
ID:
301429432
8.

epidermis_wildtype_treated_FA_1

Organism:
Mus musculus
Source name:
Epidermis from posterior ear lobe
Platform:
GPL6885
Series:
GSE59151
Download data
Sample
Accession:
GSM1429431
ID:
301429431
9.

epidermis_wildtype_2

Organism:
Mus musculus
Source name:
Epidermis from posterior ear lobe
Platform:
GPL6885
Series:
GSE59151
Download data
Sample
Accession:
GSM1429430
ID:
301429430
10.

epidermis_wildtype_1

Organism:
Mus musculus
Source name:
Epidermis from posterior ear lobe
Platform:
GPL6885
Series:
GSE59151
Download data
Sample
Accession:
GSM1429429
ID:
301429429
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Supplemental Content

db=gds|term=GSE59151[Accession]|query=1|qty=2|blobid=MCID_60ff443bbb155808c51a5586|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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