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1.

Reduced expression of mitochondrial oxidative metabolism genes in skeletal muscle of women with PCOS

(Submitter supplied) Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). Using the HG-U133 Plus 2.0 expression array from Affymetrix, we analyzed gene expression in skeletal muscle from obese women with PCOS (n=16) and age- and body mass index-matched control women (n=13) metabolically characterized by euglycemic-hyperinsulinemic clamp and indirect calorimetry. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3104
Platform:
GPL570
29 Samples
Download data: CEL
Series
Accession:
GSE6798
ID:
200006798
2.
Full record GDS3104

Insulin-resistant polycystic ovary syndrome: muscle

Analysis of vastus lateralis muscles from women with insulin-resistant polycystic ovary syndrome (PCOS). Insulin resistance in skeletal muscles is a risk factor for the development of type 2 diabetes in women with PCOS. Results provide insight into the pathogenesis of insulin resistance in PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE6798
29 Samples
Download data: CEL
DataSet
Accession:
GDS3104
ID:
3104
3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5464 Series
61 Related Platforms
162915 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570
4.

Muscle PCOS 27

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156951
ID:
300156951
5.

Muscle PCOS 25

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156950
ID:
300156950
6.

Muscle PCOS 24

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156949
ID:
300156949
7.

Muscle PCOS 22

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156948
ID:
300156948
8.

Muscle PCOS 19

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156946
ID:
300156946
9.

Muscle PCOS 16

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156763
ID:
300156763
10.

Muscle PCOS 14

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156753
ID:
300156753
11.

Muscle PCOS 13

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156752
ID:
300156752
12.

Muscle PCOS 12

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156751
ID:
300156751
13.

Muscle PCOS 11

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156750
ID:
300156750
14.

Muscle PCOS 10

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156749
ID:
300156749
15.

Muscle PCOS 9

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156512
ID:
300156512
16.

Muscle PCOS 5

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156511
ID:
300156511
17.

Muscle PCOS 4

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156510
ID:
300156510
18.

Muscle PCOS 3

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156187
ID:
300156187
19.

Muscle PCOS 1

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156186
ID:
300156186
20.

Muscle control 18

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE6798
Dataset:
GDS3104
Download data: CEL
Sample
Accession:
GSM156184
ID:
300156184
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