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Items: 6

1.

The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-Folate Therapy in Breast Cancer [Microarray expression]

(Submitter supplied) Reprogramming of cellular metabolism plays a central role in fuelling malignant transformation, and AMPK as well as the PGC-1α/ERRα axis are key regulators of this process. Intersection of gene expression and binding event datasets in breast cancer cells shows that activation of AMPK significantly increases the expression of PGC-1α/ERRα and promotes the binding of ERRα to its cognate sites. Unexpectedly, the data also reveal that ERRα, in concert with PGC-1α, negatively regulates the expression of several one-carbon metabolism genes resulting in substantial perturbations in purine biosynthesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE75727
ID:
200075727
2.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5472 Series
61 Related Platforms
163699 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570
3.

BT474_1day_AICAR_rep2

Organism:
Homo sapiens
Source name:
BT474 cells treated for 24h with AICAR
Platform:
GPL570
Series:
GSE75727 GSE75877
Download data: CEL, CHP
Sample
Accession:
GSM1964815
ID:
301964815
4.

BT474_1day_AICAR_rep1

Organism:
Homo sapiens
Source name:
BT474 cells treated for 24h with AICAR
Platform:
GPL570
Series:
GSE75727 GSE75877
Download data: CEL, CHP
Sample
Accession:
GSM1964814
ID:
301964814
5.

BT474_1day_vehicle_rep2

Organism:
Homo sapiens
Source name:
BT474 cells treated for 24h with vehicle
Platform:
GPL570
Series:
GSE75727 GSE75877
Download data: CEL, CHP
Sample
Accession:
GSM1964813
ID:
301964813
6.

BT474_1day_vehicle_rep1

Organism:
Homo sapiens
Source name:
BT474 cells treated for 24h with vehicle
Platform:
GPL570
Series:
GSE75727 GSE75877
Download data: CEL, CHP
Sample
Accession:
GSM1964812
ID:
301964812
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