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Items: 8

1.

AKT regulates de novo induction of Foxp3

(Submitter supplied) The CD4+Foxp3+ regulatory T cells play an essential role in maintaining tolerance via their suppressive function on conventional T cells. The intracellular signaling pathways that regulate Foxp3 expression are largely unknown. In this study we describe a novel inhibitory role for AKT in regulating de novo induction of Foxp3 both in vivo and in vitro. A constitutively active allele of AKT significantly diminished TGF-â induced Foxp3 induction via a rapamycin-sensitive pathway, establishing a role for the AKT-mTOR axis in Treg cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE7596
ID:
200007596
2.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4422 Series
40 Related Platforms
57633 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
3.

GFPTGF, rep3

Organism:
Mus musculus
Source name:
Tconv cells retrovirally transduced with empty vector and activated in vitro with TGFbeta
Platform:
GPL1261
Series:
GSE7596
Download data: CEL
Sample
Accession:
GSM180516
ID:
300180516
4.

GFPTGF, rep2

Organism:
Mus musculus
Source name:
Tconv cells retrovirally transduced with empty vector and activated in vitro with TGFbeta
Platform:
GPL1261
Series:
GSE7596
Download data: CEL
Sample
Accession:
GSM180515
ID:
300180515
5.

AktTGF, rep3

Organism:
Mus musculus
Source name:
Tconv cells retrovirally transduced with constituatively active Akt and activated in vitro with TGFbeta
Platform:
GPL1261
Series:
GSE7596
Download data: CEL
Sample
Accession:
GSM180513
ID:
300180513
6.

AktTGF, rep2

Organism:
Mus musculus
Source name:
Tconv cells retrovirally transduced with constituatively active Akt and activated in vitro with TGFbeta
Platform:
GPL1261
Series:
GSE7596
Download data: CEL
Sample
Accession:
GSM180510
ID:
300180510
7.

GFPTGF, rep1

Organism:
Mus musculus
Source name:
Tconv cells retrovirally transduced with empty vector and activated in vitro with TGFbeta
Platform:
GPL1261
Series:
GSE7596
Download data: CEL
Sample
Accession:
GSM176891
ID:
300176891
8.

AktTGF, rep1

Organism:
Mus musculus
Source name:
Tconv cells retrovirally transduced with constituatively active Akt and activated in vitro with TGFbeta
Platform:
GPL1261
Series:
GSE7596
Download data: CEL
Sample
Accession:
GSM176890
ID:
300176890
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