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Items: 11

1.

Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis

(Submitter supplied) Biogenesis of canonical microRNAs (miRNAs) involves multiple steps: nuclear processing of primary miRNA (pri-miRNA) by DROSHA, nuclear export of precursor miRNA (pre-miRNA) by Exportin 5 (XPO5), and cytoplasmic processing of pre-miRNA by DICER. To gain a deeper understanding of the contribution of each of these maturation steps, we deleted DROSHA, XPO5, and DICER in the same human cell line, and analyzed their effects on miRNA biogenesis. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL15520
9 Samples
Download data: TXT
Series
Accession:
GSE77989
ID:
200077989
2.

Illumina MiSeq (Homo sapiens)

Platform
Accession:
GPL15520
ID:
100015520
3.

DICER KO #45 (set 2)

Organism:
Homo sapiens
Source name:
HCT116 cell line
Platform:
GPL15520
Series:
GSE77989
Download data: TXT
Sample
Accession:
GSM2064278
ID:
302064278
4.

DICER KO #43 (set 2)

Organism:
Homo sapiens
Source name:
HCT116 cell line
Platform:
GPL15520
Series:
GSE77989
Download data: TXT
Sample
Accession:
GSM2064277
ID:
302064277
5.

XPO5 KO #19-1 (set 2)

Organism:
Homo sapiens
Source name:
HCT116 cell line
Platform:
GPL15520
Series:
GSE77989
Download data: TXT
Sample
Accession:
GSM2064276
ID:
302064276
6.

XPO5 KO #19 (set 2)

Organism:
Homo sapiens
Source name:
HCT116 cell line
Platform:
GPL15520
Series:
GSE77989
Download data: TXT
Sample
Accession:
GSM2064275
ID:
302064275
7.

Parental cells (set 2)

Organism:
Homo sapiens
Source name:
HCT116 cell line
Platform:
GPL15520
Series:
GSE77989
Download data: TXT
Sample
Accession:
GSM2064274
ID:
302064274
8.

DROSHA KO #40 (set 1) replicate 2

Organism:
Homo sapiens
Source name:
HCT116 cell line
Platform:
GPL15520
Series:
GSE77989
Download data: TXT
Sample
Accession:
GSM2064273
ID:
302064273
9.

DROSHA KO #40 (set 1) replicate 1

Organism:
Homo sapiens
Source name:
HCT116 cell line
Platform:
GPL15520
Series:
GSE77989
Download data: TXT
Sample
Accession:
GSM2064272
ID:
302064272
10.

Parental cells (set 1) replicate 2

Organism:
Homo sapiens
Source name:
HCT116 cell line
Platform:
GPL15520
Series:
GSE77989
Download data: TXT
Sample
Accession:
GSM2064271
ID:
302064271
11.

Parental cells (set 1) replicate 1

Organism:
Homo sapiens
Source name:
HCT116 cell line
Platform:
GPL15520
Series:
GSE77989
Download data: TXT
Sample
Accession:
GSM2064270
ID:
302064270
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Supplemental Content

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