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Items: 8

1.

RUNX1-ETO and RUNX1-EVI-1 differentially program the chromatin landscape in t(3;21) and t(8;21) AML but share global C/EBP-alpha dysfunction (DNase-Seq)

(Submitter supplied) RUNX1 is a frequent target of translocations in acute myeloid leukemia whereby its DNA binding domain fuses to different epigenetic regulators. To assess how different RUNX1 fusion proteins interact with the epigenome we compared the global binding patterns and the chromatin landscape of t(8;21) and t(3;21) AML which express RUNX1-ETO and RUNX1-EVI-1, respectively. We found that differential prognosis for these types of AML is reflected in fundamental differences in gene expression, chromatin landscape, binding patterns of the fusion proteins and other transcription factors as identified by genome-wide digital footprinting in patients. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: BW
Series
Accession:
GSE87284
ID:
200087284

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2500 (Homo sapiens)

Organism:
Homo sapiens
11886 Series
340700 Samples
Download data
Platform
Accession:
GPL16791
ID:
100016791

3.

SKH1_SIREVI1_D10_DNAse1Seq

Organism:
Homo sapiens
Source name:
RUNX1-EVI1 KD SKH-1 cells after 10 days
Platform:
GPL16791
Series:
GSE87284 GSE87286
Download data: BW
Sample
Accession:
GSM2326848
ID:
302326848

SRA Run Selector

4.

SKH1_SIMM_D10_DNAse1Seq

Organism:
Homo sapiens
Source name:
mismatch control SKH-1 cells after 10 days
Platform:
GPL16791
Series:
GSE87284 GSE87286
Download data: BW
Sample
Accession:
GSM2326847
ID:
302326847

SRA Run Selector

5.

sKH1_JL24_6510_DNAse1Seq

Organism:
Homo sapiens
Source name:
untreated SKH-1 cells
Platform:
GPL16791
Series:
GSE87284 GSE87286
Download data: BW
Sample
Accession:
GSM2326846
ID:
302326846

SRA Run Selector

6.

R299-PBSCs_DNAse1Seq

Organism:
Homo sapiens
Source name:
CD34+ human healthy donor
Platform:
GPL16791
Series:
GSE87284 GSE87286
Download data: BW
Sample
Accession:
GSM2326845
ID:
302326845

SRA Run Selector

7.

AML5354-t321_Patient2_DNAse1Seq

Organism:
Homo sapiens
Source name:
AML t(3;21) paitent 2
Platform:
GPL16791
Series:
GSE87284 GSE87286
Download data: BW
Sample
Accession:
GSM2326844
ID:
302326844

SRA Run Selector

8.

t321_Patient1_DNAse1Seq

Organism:
Homo sapiens
Source name:
AML t(3;21) paitent 1
Platform:
GPL16791
Series:
GSE87284 GSE87286
Download data: BW
Sample
Accession:
GSM2326843
ID:
302326843

SRA Run Selector

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