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1.

CLL in Em-TCL1 mice provides a biologically relevant model to unravel and reverse immune deficiency in human cancer.

(Submitter supplied) Immune deficiency is common in cancer, but the biological basis for this and ways to reverse it remains elusive. Here we present a mouse model of B cell chronic lymphocytic leukemia (CLL) that recapitulates changes in the non-malignant circulating T cells seen in patients with this illness.1 To validate this model, we examined changes in T cell gene expression, protein expression and function in Em-TCL1 transgenic mice as they developed CLL 2,3 and demonstrate that development of CLL in these transgenic mice is associated with changes in impaired T cell function and in gene expression in CD4 and CD8 T cells similar to those observed in patients with this disease. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
56 Samples
Download data: CEL, TXT
Series
Accession:
GSE8836
ID:
200008836
2.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4422 Series
40 Related Platforms
57633 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
3.

IV-CLL6-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219577
ID:
300219577
4.

IV-CLL5-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219576
ID:
300219576
5.

IV-CLL4-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219575
ID:
300219575
6.

IV-CLL3-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219574
ID:
300219574
7.

IV-CLL2-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219573
ID:
300219573
8.

IV-CLL1-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219572
ID:
300219572
9.

CLL12-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219571
ID:
300219571
10.

CLL11-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219570
ID:
300219570
11.

Healthy4-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219569
ID:
300219569
12.

Healthy3-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219568
ID:
300219568
13.

WT6-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219567
ID:
300219567
14.

CLL10-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219566
ID:
300219566
15.

Healthy2-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219565
ID:
300219565
16.

Healthy1-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219564
ID:
300219564
17.

WT5-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219563
ID:
300219563
18.

CLL9-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219562
ID:
300219562
19.

CLL8-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219561
ID:
300219561
20.

CLL7-CD8

Organism:
Mus musculus
Source name:
splenic CD8 T cells
Platform:
GPL1261
Series:
GSE8836
Download data: CEL, TXT
Sample
Accession:
GSM219560
ID:
300219560
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