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Items: 7

1.

Alpha2-6-linked Sialic Acids on N-Glycans Modulate Carcinoma Differentiation In Vivo

(Submitter supplied) Sialic acids on vertebrate cell surfaces mediate many biological roles. Altered expression of certain sialic acid types or their linkages can have prognostic significance in human cancer. A classic but unexplained example is enhanced α2-6-sialylation on N-glycans, resulting from over-expression of the Golgi enzyme β-galactoside:α2-6-sialyltransferase (ST6Gal-I). Previous data supporting a role for the resulting Siaα2-3Galβ1-4GlcNAc (Sia6LacNAc) structure in tumor biology were based on in vitro studies in transfected carcinoma cells, in which increased Sia6LacNAc on β1-integrins enhanced their binding to ligands, and stimulated cell motility. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3151
Platform:
GPL1261
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE9447
ID:
200009447
2.
Full record GDS3151

Beta-galactoside alpha-2,6-sialyltransferase deficient mammary tumors

Analysis of mammary tumors from animals lacking beta-galactoside alpha-2,6-sialyltransferase (ST6Gal-I). Increased ST6Gal-I expression is reported in several carcinomas including breast carcinoma. Results provide insight into the role of ST6Gal-I in tumor progression.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE9447
4 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS3151
ID:
3151
3.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4422 Series
40 Related Platforms
57633 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
4.

wild-type tumor #3375

Organism:
Mus musculus
Source name:
PyV-mT wild-type tumor
Platform:
GPL1261
Series:
GSE9447
Dataset:
GDS3151
Download data: CEL, CHP
Sample
Accession:
GSM239972
ID:
300239972
5.

St6gal1-/- tumor #3376

Organism:
Mus musculus
Source name:
PyV-mT St6gal1-/- tumor
Platform:
GPL1261
Series:
GSE9447
Dataset:
GDS3151
Download data: CEL, CHP
Sample
Accession:
GSM239971
ID:
300239971
6.

wild-type tumor #3152

Organism:
Mus musculus
Source name:
PyV-mT wild-type tumor
Platform:
GPL1261
Series:
GSE9447
Dataset:
GDS3151
Download data: CEL, CHP
Sample
Accession:
GSM239970
ID:
300239970
7.

St6gal1-/- tumor #3151

Organism:
Mus musculus
Source name:
PyV-mT St6gal1-/- tumor
Platform:
GPL1261
Series:
GSE9447
Dataset:
GDS3151
Download data: CEL, CHP
Sample
Accession:
GSM239969
ID:
300239969
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Supplemental Content

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