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Items: 9

1.

Regulation of Liver Regeneration and Hepatocarcinogenesis by Suppressor of Cytokine Signaling 3

(Submitter supplied) Suppressor of cytokine signaling 3 (SOCS3) down-regulates several signaling pathways in multiple cell types, and previous data suggest that SOCS3 may shut off cytokine activation at the early stages of liver regeneration. We developed hepatocyte-specific Socs3 knockout (Socs3 h-KO) mice to directly study the role of SOCS3 during liver regeneration after 2/3 partial hepatectomy (PH). Socs3 h-KO mice demonstrate marked enhancement of DNA replication and liver weight restoration after 2/3 PH in comparison with littermate controls. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3149
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE9549
ID:
200009549
2.
Full record GDS3149

Suppressor of cytokine signaling 3 deficiency effect on the regenerating liver

Analysis of regenerating livers of animals bearing a hepatocyte-specific Suppressor of cytokine signaling 3 gene (SOCS3) knockout. SOCS3 down-regulates several signaling pathways in multiple cell types. Results provide insight into the role of SOCS3 in liver regeneration.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE9549
6 Samples
Download data: CEL
3.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4423 Series
40 Related Platforms
57646 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
4.

SOCS3 Cre plus C

Organism:
Mus musculus
Source name:
liver
Platform:
GPL1261
Series:
GSE9549
Dataset:
GDS3149
Download data: CEL
Sample
Accession:
GSM241743
ID:
300241743
5.

SOCS3 Cre minus C

Organism:
Mus musculus
Source name:
liver
Platform:
GPL1261
Series:
GSE9549
Dataset:
GDS3149
Download data: CEL
Sample
Accession:
GSM241742
ID:
300241742
6.

SOCS3 Cre plus B

Organism:
Mus musculus
Source name:
liver
Platform:
GPL1261
Series:
GSE9549
Dataset:
GDS3149
Download data: CEL
Sample
Accession:
GSM241741
ID:
300241741
7.

SOCS3 Cre minus B

Organism:
Mus musculus
Source name:
liver
Platform:
GPL1261
Series:
GSE9549
Dataset:
GDS3149
Download data: CEL
Sample
Accession:
GSM241740
ID:
300241740
8.

SOCS3 Cre plus A

Organism:
Mus musculus
Source name:
liver
Platform:
GPL1261
Series:
GSE9549
Dataset:
GDS3149
Download data: CEL
Sample
Accession:
GSM241739
ID:
300241739
9.

SOCS3 Cre minus A

Organism:
Mus musculus
Source name:
liver
Platform:
GPL1261
Series:
GSE9549
Dataset:
GDS3149
Download data: CEL
Sample
Accession:
GSM241738
ID:
300241738
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Supplemental Content

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