GEO DataSets

(Submitter supplied) Recent microarray studies in the hippocampus of rodents or Alzheimer’s disease (AD) subjects have identified a substantial number of cellular pathways/processes correlated with aging and cognitive decline. However, the temporal relationships among these expression changes or with cognitive impairment have not been studied in depth. Here, using Affymetrix microarrays, immunohistochemistry and Morris water maze cognitive testing across 5 age groups of male F344 rats (n=9-15/group, one microarray per animal), we systematically analyzed the temporal sequence and cellular localization of aging changes in expression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3915

Platform:

GPL341

49 Samples

Download data: CEL

Analysis of hippocampi from F344 males, at 5 age points across the adult lifespan, tested on the Morris water maze (MWM) task. MWM is a dorsal hippocampal-dependent, spatial memory task. MWM performance showed an age effect. Results provide insight into the molecular basis of cognitive aging.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 age sets

Platform:

GPL341

Series:

GSE9990

49 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 21, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Array A of GeneChip Rat Expression Set 230 Has 15923 entries and was indexed 09-Apr-2003 Sequences used in the design of the array were selected from GenBank, dbEST, and RefSeq. more...

Organism:

Rattus norvegicus

68 DataSets

148 Series

2 Related Platforms

3292 Samples

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