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Items: 4

1.

Fluoxetine resistance in mice is associated with attenuated progression of a stereotyped dentate gyrus gene expression program

(Submitter supplied) Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are the most common treatment for major depression. However, approximately 50% of depressed patients fail to achieve an effective treatment response. Understanding how gene expression systems relate to treatment responses may be critical for understanding antidepressant resistance. Transcriptome profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to utilize this information to determine mechanisms underlying antidepressant treatment responses. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS5307 GDS5308
Platform:
GPL1261
38 Samples
Download data: CEL
Series
Accession:
GSE43261
ID:
200043261
2.
Full record GDS5307

Antidepressant fluoxetine effect on depression model: dorsal dentate gyrus

Analysis of dorsal dentate gyrus from adults subjected to chronic corticosterone (CORT) to induce depression-like behaviors, followed by combined treatment of CORT and selective serotonin reuptake inhibitor fluoxetine. Results provide insight into the molecular basis of antidepressant resistance.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 3 individual sets
Platform:
GPL1261
Series:
GSE43261
19 Samples
Download data: CEL
3.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4456 Series
40 Related Platforms
57985 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
4.

Dorsal Dentate Control #2

Organism:
Mus musculus
Source name:
Dorsal dentate gyrus
Platform:
GPL1261
Series:
GSE43261
Dataset:
GDS5307
Download data: CEL
Sample
Accession:
GSM1059562
ID:
301059562
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