GSM1087500[Accession] - GEO DataSets

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Items: 4

Select item 2000445921.

Restless Legs Syndrome-associated variant in MEIS1 confers altered gene expression in embryonic ganglionic eminences

(Submitter supplied) Genome-wide association studies (GWASs) identified the MEIS1 locus for Restless Legs Syndrome (RLS), but causal single nucleotide polymorphisms (SNPs) and the functional relevance have remained to be elucidated. The MEIS1 locus contains an exceptionally large number of highly conserved non-coding regions (HCNRs), which potentially function as cis-regulatory modules. We analyzed the HCNRs in the RLS-associated linkage disequilibrium (LD) block for allele-dependent enhancer activity in both zebrafish and mouse, comparing the protective and risk alleles of RLS-associated common variants. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS5299 GDS5300
Platform:: GPL6885
23 Samples

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Series

Accession:: GSE44592

ID:: 200044592

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 53002.

Restless Legs Syndrome model: embryonic forebrain

Analysis of forebrain from male and female E12.5 embryos heterozygous for the Meis1tm1Mtor allele. These animals express only one functional allele of Meis1, modeling the reduced expression of MEIS1 in Restless Legs Syndrome (RLS) patients. Results provide insight the role of MEIS1 in RLS.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 gender, 3 genotype/variation sets

Platform:: GPL6885
Series:: GSE44592
16 Samples

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DataSet

Accession:: GDS5300

ID:: 5300

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000068853.

Illumina MouseRef-8 v2.0 expression beadchip

(Submitter supplied) The MouseRef-8 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...