GEO DataSets

(Submitter supplied) 2,3,7,8-TCDD (TCDD) is a reproductive toxicant and endocrine disruptor in nearly all vertebrates, yet the mechanisms by which TCDD induces these reproductive alterations have not been fully characterized. Fish are among the most sensitive vertebrates to the toxic effects of TCDD, and even subtle physiologic changes induced by TCDD can impair reproduction. Previously, we have shown that chronic, sub-lethal exposure to TCDD decreased reproductive capacity, reduced serum estradiol and vitellogenin concentrations, and altered follicular development. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Datasets:

GDS2927 GDS2928

Platform:

GPL1319

8 Samples

Download data: CEL, EXP

Analysis of ovaries following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at concentrations of up to 100 parts per billion (ppb). TCDD is a reproductive toxicant and endocrine disruptor in vertebrates. Results provide insight into molecular mechanisms underlying TCDD toxicity.

Organism:

Danio rerio

Type:

Expression profiling by array, count, 4 dose sets

Platform:

GPL1319

Series:

GSE4859

4 Samples

Download data: CEL, EXP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html The Affymetrix GeneChip Zebrafish Genome Array can be used to study gene expression of over 14,900 Danio rerio transcripts. Sequence information for this array was selected from the following public data sources: RefSeq (July 2003), GenBank (release 136.0, June 2003), dbEST (July 2003), and UniGene (Build 54, June 2003). more...

Organism:

Danio rerio

18 DataSets

135 Series

1 Related Platform

1713 Samples

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