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Items: 4

1.

Expression data from adult Rattus liver

(Submitter supplied) Activation of the pregnane X receptor (NR1I2) by drugs and other xenobiotics stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substrates. We used microarray analysis to identify genes whose expression in rat liver was significantly altered by pregnenolone 16alpha-carbonitrile (PCN) treatment. Keywords: a single ip injection of PCN (100 mg/kg), 8 h treatment
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS2093 GDS2094
Platforms:
GPL341 GPL342
19 Samples
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Series
Accession:
GSE4959
ID:
200004959
2.
Full record GDS2094

Pregnane X receptor agonist effect on the liver (RAE230B)

Analysis of livers of animals treated with pregnenolone 16alpha-carbonitrile (PCN), a pregnane X receptor (NR1I2) agonist. NR1I2 is a member of the nuclear receptor family of ligand-activated transcription factors, and regulates the transcription of genes encoding xenobiotic metabolizing enzymes.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL342
Series:
GSE4959
9 Samples
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3.

[RAE230B] Affymetrix Rat Expression 230B Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html Array B of GeneChip Rat Expression Set 230 Has 15333 entries and was indexed 09-Apr-2003 Sequences used in the design of the array were selected from GenBank, dbEST, and RefSeq. Sequence clusters were created from Build 99 of UniGene (June 2002) and refined by analysis and comparison with a number of other publicly available databases including the Baylor College of Medicine Human Genome Sequencing Center's preliminary rat genome assembly (June 2002). more...
Organism:
Rattus norvegicus
8 DataSets
16 Series
179 Samples
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Platform
Accession:
GPL342
ID:
100000342
4.

PCN, biological rep4b

Organism:
Rattus norvegicus
Source name:
Rattus, adult liver
Platform:
GPL342
Series:
GSE4959
Dataset:
GDS2094
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Sample
Accession:
GSM111904
ID:
300111904
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