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Items: 3

1.

SIRT1 but not its increased expression is essential for lifespan extension in caloric restricted mice.

(Submitter supplied) The SIRT1 deacetylase is one of the best-studied potential mediators of some of the anti-aging effects of calorie restriction (CR); but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespan than wild type mice on an ad libitum diet. Here we report that median lifespan extension in CR heterozygote SIRT1+/- mice was identical (51%) to that observed in wild type mice but SIRT1+/- mice displayed a higher frequency of some certain pathologies. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
18 Samples
Download data: TXT
Series
Accession:
GSE46895
ID:
200046895
2.

Illumina MouseRef-8 v2.0 expression beadchip

(Submitter supplied) The MouseRef-8 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...
Organism:
Mus musculus
33 DataSets
885 Series
16579 Samples
Download data: BGX
Platform
Accession:
GPL6885
ID:
100006885
3.

Liver-Ad Lib- Homozygous knockout-replicate 3

Organism:
Mus musculus
Source name:
Liver-Ad Lib- Homozygous knockout
Platform:
GPL6885
Series:
GSE46895
Download data
Sample
Accession:
GSM1139930
ID:
301139930
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