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Items: 4

1.

TTP mRNA targets identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts

(Submitter supplied) Tristetraprolin (TTP) is a tandem CCCH zinc finger protein that was identified through its rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice, and cells derived from them, showed that TTP could bind to certain AU-rich elements in mRNAs, leading to increases in the rates of mRNA deadenylation and destruction. Known physiological target mRNAs for TTP include tumor necrosis factor alpha (TNF), granulocyte macrophage colony stimulating factor (GM-CSF) and interleukin 2 beta (IL2 beta). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2456
Platform:
GPL1261
48 Samples
Download data: CEL
Series
Accession:
GSE5324
ID:
200005324
2.
Full record GDS2456

Tristetrapolin-deficiency and mRNA decay in fibroblasts: time course

Analysis of tristetrapolin (TTP)-deficient fibroblasts after serum activation and subsequent actinomycin D treatment for up to 120 minutes. TTP is a tandem CCCH zinc finger protein that binds to AU-rich elements in mRNA, leading to increases in the rates of mRNA deadenylation and destruction.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation, 5 time sets
Platform:
GPL1261
Series:
GSE5324
48 Samples
Download data: CEL
3.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4431 Series
40 Related Platforms
57738 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
4.

TTP_KO_90ActD_BioRep5

Organism:
Mus musculus
Source name:
RNA prepared from fibroblast cell lines treated with 10% serum for 90 min followed by 0.5 µg/ml actinomycin D for 90 minutes
Platform:
GPL1261
Series:
GSE5324
Dataset:
GDS2456
Download data: CEL
Sample
Accession:
GSM120270
ID:
300120270
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