GSM1277114[Accession] - GEO DataSets

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Items: 4

Select item 2000593701.

The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. The SAGA co-activator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wide SAGA-binding profiles and changes in gene expression upon depletion of subunits of the complex. As indicators of SAGA recruitment on chromatin, we monitored in yeast and human cells the genome-wide distribution of histone H3K9 acetylation and H2B ubiquitination, which are respectively deposited or removed by SAGA. more...

Organism:: Homo sapiens; Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL13821 GPL10999
23 Samples

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Accession:: GSE59370

ID:: 200059370

PubMed Full text in PMC Similar studies

Select item 2000528602.

The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription [HeLa cells]

(Submitter supplied) The SAGA co-activator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wide SAGA-binding profiles and changes in gene expression upon depletion of subunits of the complex. As indicators of SAGA recruitment on chromatin, we monitored in yeast and human cells the genome-wide distribution of histone H3K9 acetylation and H2B ubiquitination, which are respectively deposited or removed by SAGA. more...