GSM1340534[Accession] - GEO DataSets

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Items: 4

Select item 2000556241.

Inhibiting tankyrases sensitizes KRAS mutant cancer cells to MEK inhibitors by FGFR2 feedback signaling

(Submitter supplied) Tankyrases (TNKS) play roles in Wnt signaling, telomere homeostasis and mitosis, offering attractive targets for anti-cancer treatment. Using unbiased combination screening in a large panel of cancer cell lines, we have identified a strong synergy between TNKS and MEK inhibitors in KRAS mutant cancer cells. Our study uncovers a novel function of TNKS in the relief of a feedback loop induced by MEK inhibition on FGFR2 signaling pathway. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5029
Platform:: GPL570
18 Samples

Download data: CEL

Series

Accession:: GSE55624

ID:: 200055624

Select item 50292.

SW480 KRAS-mutant colorectal cancer cell line response to dual inhibition of tankyrase and MEK: time course

Analysis of SW480 cancer cells treated with tankyrase inhibitor, MEK inhibitor, or both, for up to 16hrs. Dual inhibition of TNKS and MEK led to tumor regression. Results provide insight into molecular mechanisms underlying the synergistic effects of TNKS and MEK inhibitors in KRAS-mutant cancers.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 5 protocol, 3 time sets

Platform:: GPL570
Series:: GSE55624
18 Samples

Download data: CEL

DataSet

Accession:: GDS5029

ID:: 5029

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...