GSM1359097[Accession] - GEO DataSets

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Items: 4

Select item 2000563231.

Lin28 sustains early renal progenitors and induces Wilms tumor

(Submitter supplied) Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that over-expression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differentiation, ultimately resulting in pathology highly reminiscent of Wilms tumor.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5415
Platform:: GPL6885
8 Samples

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Series

Accession:: GSE56323

ID:: 200056323

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 54152.

Model for Wilms tumor of the kidney: time course

Analysis of kidney tumors from Lin28a transgenics at 5 weeks and 4 months of age. Overexpression of heterochronic regulator Lin28 during kidney development promotes Wilms tumor formation. Results provide insight into the role of Lin28 in Wilms tumor formation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 age, 2 disease state sets

Platform:: GPL6885
Series:: GSE56323
8 Samples

Download data

DataSet

Accession:: GDS5415

ID:: 5415

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000068853.

Illumina MouseRef-8 v2.0 expression beadchip

(Submitter supplied) The MouseRef-8 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...