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Items: 4

1.

GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia

(Submitter supplied) Transient leukemia (TL) is evident in 5-10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1-mutations (GATA1s). Here we analyzed the effect of on gene expression upon ectopic expression of Gata1s or Gata1, while simultaneously knocking down endogenous GATA1, in wild-type CD34+-hematopoietic stem and progenitor cells during myeloid differentiation. Ectopic expression of Gata1s, but not Gata1, in wild-type CD34+-hematopoietic stem and progenitor cells induced hyperproliferation of eosinophil promyelocytes in vitro. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5368
Platform:
GPL6480
9 Samples
Download data: TXT
Series
Accession:
GSE56332
ID:
200056332
2.
Full record GDS5368

N-terminal truncated GATA1-mutant effect on fetal CD34+ hematopoietic stem and progenitor cells: time course

Analysis of fetal CD34+ HSPCs expressing N-terminal truncated GATA1-mutant (GATA1s) during myeloid differentiation for 4 and 14 days. GATA1s mutations are associated with transient leukemia (TL)- in Down syndrome neonates. Results provide insight into the role of GATA1s in TL pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 protocol, 3 time sets
Platform:
GPL6480
Series:
GSE56332
9 Samples
Download data: TXT
3.

Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)

(Submitter supplied) This multi-pack (4X44K) formatted microarray represents a compiled view of the human genome as it is understood today. The sequence information used to design this product was derived from a broad survey of well known sources such as RefSeq, Goldenpath, Ensembl, Unigene and others. The resulting view of the human genome covers 41K unique genes and transcripts which have been verified and optimized by alignment to the human genome assembly and by Agilent's Empirical Validation process. more...
Organism:
Homo sapiens
21 DataSets
918 Series
4 Related Platforms
24328 Samples
Download data
Platform
Accession:
GPL6480
ID:
100006480
4.

SCR_E_1

Organism:
Homo sapiens
Source name:
FL-HSPCs, transduced with LeGO-iG-shSC, grown 0 days in myeloid differentiation medium, duplicate 1
Platform:
GPL6480
Series:
GSE56332
Dataset:
GDS5368
Download data: TXT
Sample
Accession:
GSM1359247
ID:
301359247
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