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Items: 6

1.

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Rattus norvegicus; Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL18609 GPL18615
340 Samples
Download data: CEL, GPR, TXT
Series
Accession:
GSE72088
ID:
200072088
2.

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (mRNA)

(Submitter supplied) The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has been proven successful in improving the prediction of genotoxicity in vivo and the understanding of underlying mechanisms. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18615
184 Samples
Download data: CEL
Series
Accession:
GSE72081
ID:
200072081
3.

Evaluating mRNA and microRNA profiles reveals discriminative and compound-specific responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Rattus norvegicus; Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL18609 GPL18615
120 Samples
Download data: CEL, GPR, TXT
Series
Accession:
GSE57132
ID:
200057132
4.

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Affymetrix]

(Submitter supplied) The study investigated differential gene expression in primary mouse hepatocyte mRNA following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological replicates per compound/solvent.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18615
60 Samples
Download data: CEL
Series
Accession:
GSE57129
ID:
200057129
5.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array [CDF: Mouse4302_Mm_ENTREZG.cdf Brainarray version 17.0.0]

(Submitter supplied) http://brainarray.mbni.med.umich.edu/Brainarray/Database/CustomCDF/17.0.0/entrezg.asp Protocol: This is identical to GPL1261 but a custom cdf environment was used to extract data. The cdf can be found at the link below.
Organism:
Mus musculus
5 Series
1 Related Platform
198 Samples
Download data: CDF, TXT
Platform
Accession:
GPL18615
ID:
100018615
6.

TCDD_24h_Exp3

Organism:
Mus musculus
Source name:
TCDD_24h_Exp3
Platform:
GPL18615
Series:
GSE57129 GSE57132 GSE72081 GSE72088
Download data: CEL
Sample
Accession:
GSM1375712
ID:
301375712
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