GSM146441[Accession] - GEO DataSets

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Items: 3

Select item 2000063611.

Genome position and gene amplification - expressional profiling of methotrexate resistant colonies

(Submitter supplied) We investigated the influence of genome position on propensity to amplify. First, we integrated a mutant form of DHFR into different positions in the human genome, challenged cells with methotrexate and then studied the genomic alterations arising in drug resistant cells. We observed site specific differences in methotrexate sensitivity, organization of amplicons and amplification frequency. One site was uniquely associated with a significantly enhanced propensity to amplify and recurrent amplicon boundaries, possibly implicating a rare folate sensitive fragile site in initiating amplification. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4419
12 Samples

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Accession:: GSE6361

ID:: 200006361

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000044192.

UCSF 7Hs version 2 human long oligo array

(Submitter supplied) Spotted long oligonucleotide array produced using Operon Human Genome Oligo Set Version 2 probes. This set includes 21329 oligonucleotides (mostly 69-mers) designed based upon representative sequences in build 147 of the human UniGene database. 12 negative control oligos are also included on these arrays. Protocol: Please Contact UCSF Shared Microarray Facility