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Items: 8

1.

Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2746
Platform:
GPL1261
21 Samples
Download data: CEL
Series
Accession:
GSE8000
ID:
200008000
2.
Full record GDS2746

Lmna H222P homozygous and heterozygous mutant models of Emery-Dreifuss muscular dystrophy: hearts

Analysis of hearts of A-type lamin Lmna H222P homo-/heterozygous mutants. LMNA mutations lead to autosomal dominant and recessive Emery-Dreifuss muscular dystrophy which is characterized by dilated cardiomyopathy. Results provide insight into the role of LMNA in the development of cardiomyopathy.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 genotype/variation sets
Platform:
GPL1261
Series:
GSE8000
21 Samples
Download data: CEL
3.

Comparison between gene expression in heart from Emd KO and control mice

(Submitter supplied) The present research is devoted to the identification of gene(s) severely affected by EMD mutations, leading to striated muscle laminopathies and more specifically the cardiomyopathy. For this purpose, we developped a large-scale gene expression approach on heart and skeletal tissues from Emd KO mouse model. Keywords: disease state modification
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2884
Platform:
GPL1261
14 Samples
Download data: CEL
Series
Accession:
GSE6399
ID:
200006399
4.

Comparison between gene expression in heart from Lmna H222P homozygous and control mice

(Submitter supplied) The present research is devoted to the identification of gene(s) severely affected by LMNA mutations, leading to striated muscle laminopathies and more specifically the cardiomyopathy. For this purpose, we developped a large-scale gene expression approach on heart and skeletal tissues from Lmna H222P heterozygous Knock-In mouse model. Keywords: disease state modification
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
14 Samples
Download data: CEL
Series
Accession:
GSE6398
ID:
200006398
5.

Comparison between gene expression in heart from Lmna H222P heterozygous and control mice

(Submitter supplied) The present research is devoted to the identification of gene(s) severely affected by LMNA mutations, leading to striated muscle laminopathies and more specifically the cardiomyopathy. For this purpose, we developped a large-scale gene expression approach on heart and skeletal tissues from Lmna H222P heterozygous Knock-In mouse model. Keywords: disease state modification
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
15 Samples
Download data: CEL
Series
Accession:
GSE6397
ID:
200006397
6.
Full record GDS2884

X-linked Emery-Dreifuss muscular dystrophy model and cardiomyopathy

Analysis of hearts of mutants lacking EMD, a gene encoding an A-type lamin. Mutations in EMD cause X-linked Emery-Dreifuss muscular dystrophy (EDMD). Results provide insight into the molecular mechanisms involved in the development of cardiomyopathy in X-linked EDMD.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE6399
14 Samples
Download data: CEL
DataSet
Accession:
GDS2884
ID:
2884
7.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4431 Series
40 Related Platforms
57738 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
8.

Control male 8

Organism:
Mus musculus
Source name:
whole heart
Platform:
GPL1261
Series:
GSE6397 GSE6398 GSE6399 GSE8000
Datasets:
GDS2746 GDS2884
Download data: CEL
Sample
Accession:
GSM147465
ID:
300147465
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Supplemental Content

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