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Items: 4

1.

The oncogene EVI1 enhances transcriptional and biological responses of human myeloid cells to all-trans retinoic acid [U937]

(Submitter supplied) The product of the ecotropic virus integration site 1 (EVI1) gene, whose overexpression is associated with a poor prognosis in myeloid leukemias and some epithelial tumors, regulates gene transcription both through direct DNA binding and through modulation of the activity of other sequence specific transcription factors. Previous results from our laboratory have shown that EVI1 influenced transcription regulation in response to the myeloid differentiation inducing agent, all-trans retinoic acid (ATRA), in a dual manner: it enhanced ATRA induced transcription of the RARb gene, but repressed the ATRA induction of the EVI1 gene itself. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5613
Platform:
GPL570
12 Samples
Download data: CEL
Series
Accession:
GSE66854
ID:
200066854
2.
Full record GDS5613

All-trans retinoic acid effect on U937 myeloid cells overexpressing ecotropic virus integration site 1

Analysis of EVI1-overexpressing U937 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE66854
12 Samples
Download data: CEL
3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5500 Series
61 Related Platforms
165146 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570
4.

U937_EVI1 DMSO replicate 3

Organism:
Homo sapiens
Source name:
U937_EVI1 cells, 24 h DMSO treatment
Platform:
GPL570
Series:
GSE66854
Dataset:
GDS5613
Download data: CEL
Sample
Accession:
GSM1633350
ID:
301633350
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