GSM1692593[Accession] - GEO DataSets

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Items: 4

Select item 2000690781.

Comparison of the gene expression profiles of carfilzomib-resistant derivatives versus parental human myeloma cell lines

(Submitter supplied) KMS-11 and KMS-34 cells were exposed to stepwise increasing concentrations of carfilzomib over a period of 18 weeks: cells adapted to growth in 4 nM carfilzomib by 4 weeks, in 6 nM in another 6 weeks and in 12 nM after a further 8 weeks. The resulting cell cultures, denoted KMS-11/Cfz and KMS-34/Cfz, respectively, retained resistance to carfilzomib even when tested after removal of selective pressure for approximately 8 weeks.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5826
Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE69078

ID:: 200069078

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 58262.

Multiple myeloma cell lines with acquired resistance to chemotherapeutic agent carfilzomib

Analysis of proteasome inhibitor carfilzomib-resistant multiple myeloma (MM) cell lines KMS-11/Cfz and KMS-34/Cfz, after 1 week of growth in the absence of carfilzomib. Results provide insight into the molecular mechanisms underlying the acquisition of proteasome inhibitor resistance in MM.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 cell line, 2 cell type sets

Platform:: GPL570
Series:: GSE69078
12 Samples

Download data: CEL

DataSet

Accession:: GDS5826

ID:: 5826

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...