GSM1842582[Accession] - GEO DataSets

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Items: 3

Select item 2000716621.

Gene expression data from mouse squamous cell carcinoma cells

(Submitter supplied) We describe a function of focal adhesion kinase (FAK) in driving anti-tumor immune evasion. The kinase activity of nuclear-targeted FAK in squamous cancer cells drives exhaustion of CD8+ T-cells and recruitment of regulatory T-cells by transcriptionally regulating chemokine/cytokine and ligand-receptor networks, including transcription of Ccl5 that is crucial. These changes inhibit antigen-primed cytotoxic CD8+ T-cell activity, permitting growth of FAK-expressing tumors. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL20766
6 Samples

Download data: CEL

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Accession:: GSE71662

ID:: 200071662

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000207662.

[Mouse4302_Mm_ENSG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [CDF: Mouse4302_Mm_ENSG_17.0.0]

(Submitter supplied) This is identical to GPL1261 but a custom CDF environment was used to extract data [Brainarray Version 17, Mouse4302_Mm_ENSG_17.0.0].