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Items: 4

1.

Gene expression profiling in skeletal muscle of PCOS after pioglitazone therapy

(Submitter supplied) Insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes. Studies have shown that thiazolidinediones (TZD) improve metabolic disturbances in PCOS patients. We hypothesized that the effect of TZD in PCOS is in part mediated by changes in the transcriptional profile of muscle favoring insulin sensitivity. Using Affymetrix microarrays, we examined the effect of pioglitazone (30 mg/day for 16 weeks) on gene expression in skeletal muscle of 10 obese women with PCOS metabolically characterized by a euglycemic-hyperinsulinemic clamp. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS4132 GDS4133
Platform:
GPL570
43 Samples
Download data: CEL
Series
Accession:
GSE8157
ID:
200008157
2.
Full record GDS4133

Obese women with polycystic ovary syndrome and obese, healthy women: skeletal muscle

Analysis of skeletal muscle from obese women with polycystic ovary syndrome (PCOS) and obese, healthy women. Results provide insight into whether pioglitazone ameliorates preexisting abnormalities in PCOS patients.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE8157
23 Samples
Download data: CEL
3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5477 Series
61 Related Platforms
164064 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570
4.

Muscle PCOS control 9

Organism:
Homo sapiens
Source name:
Vastus lateralis muscle
Platform:
GPL570
Series:
GSE8157
Dataset:
GDS4133
Download data: CEL
Sample
Accession:
GSM201854
ID:
300201854
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