(Submitter supplied) Gene regulatory networks are pivotal for many biological processes. In mouse embryonic stem cells (mESCs) the transcriptional network can be divided into three functionally distinct modules: Polycomb, Core and Myc. The Polycomb module represses developmental genes, while the Myc module is associated with proliferative functions and its mis-regulation is linked to cancer development. Here, we show that in mESCs the Polycomb Repressive Complex 2 (PRC2) associated protein EPOP (a.k.a C17orf96, esPRC2p48, E130012A19Rik) co-localizes at chromatin with members of the Myc and Polycomb module.
more...- Organism:
- Homo sapiens; Mus musculus
- Type:
- Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
- Platforms:
- GPL9185 GPL9052
- 29 Samples
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