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Items: 4

1.

Genome-wide analysis of Phgdh inactivation in murine embryonic head

(Submitter supplied) D-3-Phosphoglycerate dehydrogenase (Phgdh; EC 1.1.1.95) is a necessary enzyme for de novo L-serine biosynthesis via the phosphorylated pathway. We demonstrated previously that Phgdh is expressed exclusively by neuroepithelium and radial glia in developing mouse brain and later mainly by astrocytes. Mutations in the human PHGDH gene cause serine deficiency disorders (SDD) associated with severe neurological symptoms such as congenital microcephaly, psychomotor retardation, and intractable seizures. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2874
Platform:
GPL1261
8 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE8555
ID:
200008555
2.
Full record GDS2874

D-3-phosphoglycerate dehydrogenase deficiency effect on the embryonic head

Analysis of embryonic head tissue lacking D-3-phosphoglycerate dehydrogenase (Phgdh). Mutations in human PHGDH gene cause serine deficiency disorders like congenital microcephaly and psychomotor retardation. Results provide insight into the pathogenesis of SDD.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE8555
8 Samples
Download data: CEL, CHP, EXP
DataSet
Accession:
GDS2874
ID:
2874
3.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4431 Series
40 Related Platforms
57738 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
4.

Gene expression profiling of Phgdh knockout embryo wild3

Organism:
Mus musculus
Source name:
Head RNA of littermate wild@E13.5 No.3
Platform:
GPL1261
Series:
GSE8555
Dataset:
GDS2874
Download data: CEL, CHP, EXP
Sample
Accession:
GSM212562
ID:
300212562
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