GEO DataSets

(Submitter supplied) We recently surveyed the relationship between the human brain transcriptome and genome in a series of neuropathologically normal postmortem samples. We now have analyzed additional samples with a confirmed pathologic diagnosis of late onset Alzheimer's disease (LOAD, final n=187 controls, 176 cases). Nine percent of the cortical transcripts we analyzed had expression profiles correlated with their genotypes in the combined cohort and approximately 5% of transcripts had SNP-transcript relationships that could distinguish LOAD samples. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2700

363 Samples

Download data

(Submitter supplied) It is widely assumed that genetic differences in gene expression will underpin much of the differences between individuals and many of the quantitative traits of interest to geneticists. Despite this, there has been little work on genetic variability in human gene expression and almost none in the human brain. This is because the tools for assessing this genetic variability were not available. With whole genome SNP genotyping arrays and whole transcriptome expression arrays, these experiments have now become feasible. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2700

200 Samples

Download data

(Submitter supplied) The Sentrix® HumanRef-8 BeadChip can be used to study expression of over 23,000 human transcripts from the NCBI RefSeq database. Researchers can generate whole-genome expression profiles for 8 samples in parallel on a single BeadChip. The array is composed of 3 micron features with average feature redundancy of 30-fold. All features are quality controlled by sequential hybridizations process called array decoding. more...

Organism:

Homo sapiens

8 DataSets

38 Series

1586 Samples

Download data