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Items: 6

1.

Gene expression profiles of striatum and cerebellum from knock-in mouse model of Huntington's disease

(Submitter supplied) Huntington’s disease (HD) involves marked early neurodegeneration in the striatum whereas the cerebellum is relatively spared despite the ubiquitous expression of full-length mutant huntingtin, implying that inherent tissue-specific differences determine susceptibility to the HD CAG mutation. To understand this tissue specificity, we compared early mutant huntingtin-induced gene expression changes in striatum to those in cerebellum in young Hdh CAG knock-in mice, prior to onset of evident pathological alterations. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3935
Platform:
GPL1261
24 Samples
Download data: CEL
Series
Accession:
GSE9038
ID:
200009038
2.
Full record GDS3935

Huntington's disease CAG knock-in effect on striatum and cerebellum

Analysis of striatum and cerebellum of HdhQ111/Q111 CAG knock-ins (expressing full-length huntingtin with 111-glutamines) and wild-type HdhQ7/Q7 mice (expressing full-length huntingtin with 7-glutamines). Results provide insight into tissue-specific differences in susceptibility to HD CAG mutation.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 tissue sets
Platform:
GPL1261
Series:
GSE9038
24 Samples
Download data: CEL
3.

A novel approach to investigate tissue-specific trinucleotide repeat instability

(Submitter supplied) In Huntington’s disease (HD), an expanded CAG repeat produces characteristic striatal neurodegeneration. Interestingly, the HD CAG repeat, whose length determines age at onset, undergoes tissue-specific somatic instability, predominant in the striatum, suggesting that tissue-specific CAG length changes could modify the disease process. Therefore, understanding the mechanisms underlying the tissue specificity of somatic instability may provide novel routes to therapies. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4534
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE19780
ID:
200019780
4.
Full record GDS4534

HdhQ111 knock-in model of Huntington's disease: striatum and cerebellum

Analysis of striatum and cerebellum from a HdhQ111/111 knock-in model of Huntington's disease (HD). The 10-week HdhQ111/111 mice exhibit somatic instability in striatum but not in cerebellum. Results provide insight into the molecular basis of tissue-specific somatic instability.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 tissue sets
Platform:
GPL1261
Series:
GSE19780
12 Samples
Download data: CEL
5.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4431 Series
40 Related Platforms
57738 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
6.

Hdh+/Hdh+ cerebellum at 3~10 weeks biological rep 6

Organism:
Mus musculus
Source name:
Hdh+/Hdh+ cerebellum at 3~10 weeks biological rep 6
Platform:
GPL1261
Series:
GSE9038 GSE19780
Datasets:
GDS3935 GDS4534
Download data: CEL
Sample
Accession:
GSM229458
ID:
300229458
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